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• (author = "George, James W." AND subject = "DNA Dynamics and Chromosome Structure")
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author = "George, James W." > : "DNA Dynamics and Chromosome Structure" (x)
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Restoration of Nucleotide Excision Repair in a Helicase-Deficient XPD Mutant from Intragenic Suppression by a Trichothiodystrophy Mutation

Author(s) : George, James W. , Salazar, Edmund P. , Vreeswijk, Maaike P. G. , Lamerdin, Jane E. , Reardon, Joyce T. , Zdzienicka, Malgorzata Z.
Description : The UV-sensitive V-H1 cell line has a T46I substitution mutation in the Walker A box in both alleles of XPD and lacks DNA helicase activity. We characterized three partial revertants that curiously display intermediate UV cytotoxicity (2- to 2.5-fold) but normal levels of UV-induced hprt mutations. ...
Repository : Europe PubMed Central
Language(s) : English
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