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author = "Freyer, Jennifer" > : "Brief Definitive Reports" (x)
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Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease

Author(s) : Lahl, Katharina , Loddenkemper, Christoph , Drouin, Cathy , Freyer, Jennifer , Arnason, Jon , Eberl, Gérard , Hamann, Alf
Description : The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3–4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central cont...
Repository : Europe PubMed Central
Language(s) : English
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