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• (author = "Chen, X." AND repositories = "ORBi (University of Liège)")
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author = "Chen, X." > : "ORBi (University of Liège)" (x)
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Found 2 documents, displaying page 1 of 1

Simultaneous Determination of Deoxyribonucleoside in the Presence of Ribonucleoside Triphosphates in Human Carcinoma Cells by High-Performance Liquid Chromatography

Author(s) : Decoster, L-A , Chen, X , Lejeune, F , Mirimanoff, R-O , Biolla, J , COUCKE, Philippe
Description : Simultaneous determination of ribonucleoside and deoxyribonucleoside triphosphates in cells by HPLC is an analytical challenge since the concentration of dNTP present in mammalian cells is several orders of magnitude lower than the corresponding NTP. Hence, the quantitation of dNTP in cells is gener...
Repository : ORBi (University of Liège)
Language(s) : English

The ribonucleoside diphosphate reductase inhibitor (E)-2'-Deoxy-(fluoromethylene) cytidine, acts as a cytotoxic radiosensitizer on human cancer cell lines in vitro.

Author(s) : Coucke, Philippe , Decosterd, L-A , Li, Y-X , Cottin, E , Chen, X , Sun, L-Q , Stern, S , Paschoud, N , Denekamp, J
Description : ABSTRACT (E)-2*-Deoxy-(fluoromethylene)cytidine (FMdC) is known as an inhibitor of ribonucleoside diphosphate reductase, a key enzyme in the de novo pathway of DNA synthesis. FMdC was tested as a modifier of radiation response in vitro on a human colon carcinoma cell line (WiDr), and the observed ra...
Repository : ORBi (University of Liège)
Language(s) : English
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Found 2 documents, displaying page 1 of 1