Results
author = "Zheng, Zhili"
1
Found 7 documents, displaying page 1 of 1
Protein L: a novel reagent for the detection of Chimeric Antigen Receptor (CAR) expression by flow cytometry
Description :
Abstract
Background
There has been significant progress in the last two decades on the design of chimeric antigen receptors (CAR) for adoptive immunotherapy targeting tumor-associated antigens. Structurally CARs consist of a single chain antibody fragment directed against a tumor-as...
Repository :
DOAJ-Articles
Language(s) :
English
Protein L: a novel reagent for the detection of Chimeric Antigen Receptor (CAR) expression by flow cytometry
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Lack of specific γ-retroviral vector long terminal repeat promoter silencing in patients receiving genetically engineered lymphocytes and activation upon lymphocyte restimulation
Description :
Retroviral transduction of tumor antigen-specific T-cell receptor (TCR) genes into lymphocytes redirects T cells to lyse tumors. Furthermore, adoptive transfer of these lymphocytes has mediated objective responses in patients with metastatic cancer. From 2004 to 2006, more than 40 patients were trea...
Repository :
Europe PubMed Central
Language(s) :
English
Improving Adoptive T Cell Therapy by Targeting and Controlling IL-12 Expression to the Tumor Environment
Author(s) :
Zhang, Ling
,
Kerkar, Sid P
,
Yu, Zhiya
,
Zheng, Zhili
,
Yang, Shicheng
,
Restifo, Nicholas P
,
Rosenberg, Steven A
,
Morgan, Richard A
Description :
Interleukin-12 (IL-12) is an important immunostimulatory cytokine, yet its clinical application has been limited by the systemic toxicity associated with its administration. In this work, we developed a strategy to selectively deliver IL-12 to the tumor environment using genetically engineered lymph...
Repository :
Europe PubMed Central
Language(s) :
English
The Chapel Hill hemophilia A dog colony exhibits a factor VIII gene inversion
Author(s) :
Lozier, Jay N.
,
Dutra, Amalia
,
Pak, Evgenia
,
Zhou, Nan
,
Zheng, Zhili
,
Nichols, Timothy C.
,
Bellinger, Dwight A.
,
Read, Marjorie
Description :
In the Chapel Hill colony of factor VIII-deficient dogs, abnormal sequence (ch8, for canine hemophilia 8, GenBank no. AF361485) follows exons 1–22 in the factor VIII transcript in place of exons 23–26. The canine hemophilia 8 locus (ch8) sequence was found in a 140-kb normal dog genomic DNA bacteria...
Repository :
Europe PubMed Central
Language(s) :
English
Lentiviral Vector Design for Optimal T Cell Receptor Gene Expression in the Transduction of Peripheral Blood Lymphocytes and Tumor-Infiltrating Lymphocytes
Author(s) :
Jones, Stephanie
,
Peng, Peter D.
,
Yang, Shicheng
,
Hsu, Cary
,
Cohen, Cyrille J.
,
Zhao, Yangbing
,
Abad, John
,
Zheng, Zhili
Description :
Lentiviral vectors containing promoters of distinct origins, that is, strong viral promoters (cytomegalovirus [CMV] and murine stem cell virus [MSCV]), a cellular promoter (phosphoglycerate kinase [PGK]), and two composite promoters (CAG [a composite promoter sequence comprised of the CMV enhancer a...
Repository :
Europe PubMed Central
Language(s) :
English
Cytokine-independent growth and clonal expansion of a primary human CD8+ T-cell clone following retroviral transduction with the IL-15 gene
Author(s) :
Hsu, Cary
,
Jones, Stephanie A.
,
Cohen, Cyrille J.
,
Zheng, Zhili
,
Kerstann, Keith
,
Zhou, Juhua
,
Robbins, Paul F.
,
Peng, Peter D.
Description :
Malignancies arising from retrovirally transduced hematopoietic stem cells have been reported in animal models and human gene therapy trials. Whether mature lymphocytes are susceptible to insertional mutagenesis is unknown. We have characterized a primary human CD8+ T-cell clone, which exhibited log...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 7 documents, displaying page 1 of 1