Results
author = "Voelkel, Norbert F."
Hypoxia-induced pulmonary vascular remodeling: a model for what human disease?
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Molecular pathogenesis of emphysema
Description :
Emphysema is one manifestation of a group of chronic, obstructive, and frequently progressive destructive lung diseases. Cigarette smoking and air pollution are the main causes of emphysema in humans, and cigarette smoking causes emphysema in rodents. This review examines the concept of a homeostati...
Repository :
Europe PubMed Central
Language(s) :
English
Plexiform Lesion in Severe Pulmonary Hypertension: Association with Glomeruloid Lesion
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension
Description :
Abstract
Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies hav...
Repository :
DOAJ-Articles
Language(s) :
English
Estrogen exposure, obesity and thyroid disease in women with severe pulmonary hypertension
Description :
Severe pulmonary hypertension is a lethal group of disorders which preferentially afflicts women. It appears that in recent years the patient profile has shifted towards older, obese, and postmenopausal women, suggesting that endocrine factors may be important. Several studies have revealed an incre...
Repository :
Europe PubMed Central
Language(s) :
English
Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation
Description :
Abstract
Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized by structural alterations of microscopically small pulmonary arterioles. The vascular lesions in this group of pulmonary hypertensive diseases show actively proliferating endothelial cells wi...
Repository :
DOAJ-Articles
Language(s) :
English
Reversible or Irreversible Remodeling in Pulmonary Arterial Hypertension
Description :
Vascular remodeling is an important pathological feature of pulmonary arterial hypertension (PAH), which leads to increased pulmonary vascular resistance, with marked proliferation of pulmonary artery smooth muscle cells (SMC) and/or endothelial cells (EC). Successful treatment of experimental PAH w...
Repository :
Europe PubMed Central
Language(s) :
English
COPD/emphysema: The vascular story
Description :
In this perspective, we review published data which support the concept that many or most chronic and progressive lung diseases also involve the lung vessels and that microvascular abnormalities and endothelial cell death contribute to the pathobiology of emphysema. Lung vessel maintenance depends o...
Repository :
Europe PubMed Central
Language(s) :
English
Endothelial cells and pulmonary arterial hypertension: apoptosis, proliferation, interaction and transdifferentiation
Description :
Severe pulmonary arterial hypertension, whether idiopathic or secondary, is characterized by structural alterations of microscopically small pulmonary arterioles. The vascular lesions in this group of pulmonary hypertensive diseases show actively proliferating endothelial cells without evidence of a...
Repository :
Europe PubMed Central
Language(s) :
English
Hypoxia Impairs Vasodilation in the Lung
Description :
Alveolar hypoxia causes pulmonary vasoconstriction; we investigated whether hypoxia could also impair pulmonary vasodilation. We found in the isolated perfused rat lung a delay in vasodilation following agonist-induced vasoconstriction. The delay was not due to erythrocyte or plasma factors, or to a...
Repository :
Europe PubMed Central
Language(s) :
English