Results
author = "Upcroft, Jacqueline A."
1
Found 9 documents, displaying page 1 of 1
Drug Targets and Mechanisms of Resistance in the Anaerobic Protozoa
Description :
The anaerobic protozoa Giardia duodenalis, Trichomonas vaginalis, and Entamoeba histolytica infect up to a billion people each year. G. duodenalis and E. histolytica are primarily pathogens of the intestinal tract, although E. histolytica can form abscesses and invade other organs, where it can be f...
Repository :
Europe PubMed Central
Language(s) :
English
Drug Susceptibility Testing of Anaerobic Protozoa
Description :
A simple technique for routine, reproducible global surveillance of the drug susceptibility status of the anaerobic protozoa Trichomonas, Entamoeba, and Giardia is described. Data collected using this technique can be readily compared among different laboratories and with previously reported data. T...
Repository :
Europe PubMed Central
Language(s) :
English
Rearranged Subtelomeric rRNA Genes in Giardia duodenalis
Description :
Giardia duodenalis has linear chromosomes capped with typical eukaryotic repeats [(TAGGG)n], subtelomeric rRNA genes, and telomere gene units. The absence of two closely associated NotI sites in the large-subunit rRNA gene was used as an indicator in hybridizations of one- and two-dimensional NotI-c...
Repository :
Europe PubMed Central
Language(s) :
English
Efficacy of New 5-Nitroimidazoles against Metronidazole-Susceptible and -Resistant Giardia, Trichomonas, and Entamoeba spp.
Author(s) :
Upcroft, Jacqueline A.
,
Campbell, Raymond W.
,
Benakli, Kamel
,
Upcroft, Peter
,
Vanelle, Patrice
Description :
The efficacies of 12 5-nitroimidazole compounds and 1 previously described lactam-substituted nitroimidazole with antiparasitic activity, synthesized via SRN1 and subsequent reactions, were assayed against the protozoan parasites Giardia duodenalis, Trichomonas vaginalis, and Entamoeba histolytica. ...
Repository :
Europe PubMed Central
Language(s) :
English
5-Nitroimidazole Drugs Effective against Metronidazole-Resistant Trichomonas vaginalis and Giardia duodenalis
Author(s) :
Upcroft, Jacqueline A.
,
Dunn, Linda A.
,
Wright, Janelle M.
,
Benakli, Kamel
,
Upcroft, Peter
,
Vanelle, Patrice
Description :
Metronidazole (Mz)-resistant Giardia and Trichomonas were inhibited by 1 of 30 new 5-nitroimidazole drugs. Another five drugs were effective against some but not all of the Mz-resistant parasites. This study provides the incentive for the continued design of 5-nitroimidazole drugs to bypass cross-re...
Repository :
Europe PubMed Central
Language(s) :
English
Orally Administered Giardia duodenalis Extracts Enhance an Antigen-Specific Antibody Response
Author(s) :
Dunn, Linda A.
,
Upcroft, Jacqueline A.
,
Fowler, Elizabeth V.
,
Matthews, Ben S.
,
Upcroft, Peter
Description :
We have identified novel adjuvant activity in specific cytosol fractions from trophozoites of Giardia isolate BRIS/95/HEPU/2041 (J. A. Upcroft, P. A. McDonnell, and P. Upcroft, Parasitol. Today, 14:281–284, 1998). Adjuvant activity was demonstrated in the systemic and mucosal compartments when Giard...
Repository :
Europe PubMed Central
Language(s) :
English
Impaired Parasite Attachment as Fitness Cost of Metronidazole Resistance in Giardia lamblia▿
Author(s) :
Tejman-Yarden, Noa
,
Millman, Maya
,
Lauwaet, Tineke
,
Davids, Barbara J.
,
Gillin, Frances D.
,
Dunn, Linda
,
Upcroft, Jacqueline A.
Description :
Infections with the diarrheagenic protozoan pathogen Giardia lamblia are most commonly treated with metronidazole (Mz). Treatment failures with Mz occur in 10 to 20% of cases and Mz resistance develops in the laboratory, yet clinically, Mz-resistant (Mzr) G. lamblia has rarely been isolated from pat...
Repository :
Europe PubMed Central
Language(s) :
English
Pyruvate:ferredoxin oxidoreductase and thioredoxin reductase are involved in 5-nitroimidazole activation while flavin metabolism is linked to 5-nitroimidazole resistance in Giardia lamblia
Author(s) :
Leitsch, David
,
Burgess, Anita G.
,
Dunn, Linda A.
,
Krauer, Kenia G.
,
Tan, Kevin
,
Duchêne, Michael
,
Upcroft, Peter
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis
Author(s) :
Carlton, Jane M.
,
Hirt, Robert P.
,
Silva, Joana C.
,
Delcher, Arthur L.
,
Schatz, Michael
,
Zhao, Qi
,
Wortman, Jennifer R.
Description :
We describe the genome sequence of the protist Trichomonas vaginalis, a sexually transmitted human pathogen. Repeats and transposable elements comprise about two-thirds of the ~160-megabase genome, reflecting a recent massive expansion of genetic material. This expansion, in conjunction with ...
Repository :
UnissResearch
Language(s) :
Undetermined
1
Found 9 documents, displaying page 1 of 1