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author = "Shen, Yongquan"
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Found 3 documents, displaying page 1 of 1
Src Induces Podoplanin Expression to Promote Cell Migration*
Description :
Nontransformed cells can force tumor cells to assume a normal morphology and phenotype by the process of contact normalization. Transformed cells must escape this process to become invasive and malignant. However, mechanisms underlying contact normalization have not been elucidated. Here, we have id...
Repository :
Europe PubMed Central
Language(s) :
English
Src activates Abl to augment Robo1 expression in order to promote tumor cell migration
Author(s) :
Khusial, P. Raaj
,
Vadla, Bhaskar
,
Krishnan, Harini
,
Ramlall, Trudy F.
,
Shen, Yongquan
,
Ichikawa, Hitoshi
,
Geng, Jian-Guo
Description :
Cell migration is an essential step in cancer invasion and metastasis. A number of orchestrated cellular events involving tyrosine kinases and signaling receptors enable cancer cells to dislodge from primary tumors and colonize elsewhere in the body. For example, activation of the Src and Abl kinase...
Repository :
Europe PubMed Central
Language(s) :
English
Plant Lectin Can Target Receptors Containing Sialic Acid, Exemplified by Podoplanin, to Inhibit Transformed Cell Growth and Migration
Author(s) :
Ochoa-Alvarez, Jhon Alberto
,
Krishnan, Harini
,
Shen, Yongquan
,
Acharya, Nimish K.
,
Han, Min
,
McNulty, Dean E.
,
Hasegawa, Hitoki
Description :
Cancer is a leading cause of death of men and women worldwide. Tumor cell motility contributes to metastatic invasion that causes the vast majority of cancer deaths. Extracellular receptors modified by α2,3-sialic acids that promote this motility can serve as ideal chemotherapeutic targets. For exam...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 3 documents, displaying page 1 of 1