Results
author = "Reynaud, Claude-Agnès"
Do developing B cells need antigen?
Description :
Just as potentially useful T cells are positively selected by MHC–peptide complexes in the thymus, it has been proposed that self or commensal bacterial epitopes might select B cell populations with the capacity to recognize polysaccharide or protein structures on pathogens. Recent studies indicate ...
Repository :
Europe PubMed Central
Language(s) :
English
DNA polymerases in adaptive immunity.
Description :
To cope with an unpredictable variety of potential pathogenic insults, the immune system must generate an enormous diversity of recognition structures, and it does so by making stepwise modifications at key genetic loci in each lymphoid cell. These modifications proceed through the action of lymphoi...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
A bird's eye view on human B cells.
Description :
We show in this review that there is a continuum between the chicken B-cell system classified as the first GALT model described and the human B-cell system. We propose that humans have conserved for one B-cell subpopulation, the marginal zone B-cell subset in charge of T-independent responses, the s...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
A human equivalent of mouse B-1 cells?
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Nonoverlapping functions of DNA polymerases mu, lambda, and terminal deoxynucleotidyltransferase during immunoglobulin V(D)J recombination in vivo.
Description :
DNA polymerases mu (pol mu), lambda (pol lambda), and terminal deoxynucleotidyltransferase (TdT) are enzymes of the pol X family that share homology in sequence and functional domain organization. We showed previously that pol mu participates in light chain but surprisingly not heavy chain gene rear...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Defect in IgV gene somatic hypermutation in Common Variable Immuno-Deficiency syndrome
Author(s) :
Levy, Yves
,
Gupta, Neetu
,
Le Deist, Françoise
,
Garcia, Corinne
,
Fischer, Alain
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Common Variable Immuno-Deficiency (CVID) is the most common symptomatic primary antibody-deficiency syndrome, but the basic immunologic defects underlying this syndrome are not well defined. We report here that among eight patients studied (six CVID and two hypogammaglobulinemic patients with recurr...
Repository :
Europe PubMed Central
Language(s) :
English
DNA polymerase η is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse
Author(s) :
Delbos, Frédéric
,
Aoufouchi, Said
,
Faili, Ahmad
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2–MSH6 proteins, together with DNA polymerase η (pol η). However, residual A/T mutagenesis is still observed up...
Repository :
Europe PubMed Central
Language(s) :
English
Contribution of DNA polymerase η to immunoglobulin gene hypermutation in the mouse
Author(s) :
Delbos, Frédéric
,
De Smet, Annie
,
Faili, Ahmad
,
Aoufouchi, Said
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase η, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V p...
Repository :
Europe PubMed Central
Language(s) :
English
DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.
Author(s) :
Delbos, Frédéric
,
Aoufouchi, Said
,
Faili, Ahmad
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase eta (pol eta). However, residual A/T mutagenesis is still observe...
Repository :
HAL - Hyper Article on Line
Language(s) :
English
Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.
Author(s) :
Delbos, Frédéric
,
De Smet, Annie
,
Faili, Ahmad
,
Aoufouchi, Said
,
Weill, Jean-Claude
,
Reynaud, Claude-Agnès
Description :
The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V...
Repository :
HAL - Hyper Article on Line
Language(s) :
English