Results
author = "Renes, I.B."
1
Found 7 documents, displaying page 1 of 1
The intestinal epithelium during damage and regeneration : cell type-specific responses in experimental colitis and after cytostatic drug treatment
Author(s) :
Renes, I.B.
Description :
In the first part of this thesis the role of the colonic epithelium and in particular its associated
mucus-layer during IBD and in several experimental colitis models is discussed (Chapter 2).
In Chapter 3-5 our investigations regarding the colonic epithelium in rat during the different
phases ofDSS...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
A novel method to determine small intestinal barrier function in human neonates in vivo
Author(s) :
Schaart, M W
,
Schierbeek, H
,
de Bruijn, A C J M
,
Tibboel, D
,
van Goudoever, J B
,
Renes, I B
Description :
Repository :
Europe PubMed Central
Language(s) :
English
Combined defects in epithelial and immunoregulatory factors exacerbate the pathogenesis of inflammation: Mucin 2-interleukin 10-deficient mice
Author(s) :
Sluis, M. van der
,
Bouma, J.
,
Vincent, A.
,
Velcich, A.
,
Carraway, K.L.
,
Büller, H.A.
,
Einerhand, A.W.C.
,
Goudoever, J.B. van
Description :
Expression of the mucin MUC2, the structural component of the colonic mucus layer, is lowered in ulcerative colitis. Furthermore, interleukin (IL)-10 knockout (IL-10-/-) mice develop colitis and have reduced Muc2 levels. Our aim was to obtain insight into the role of Muc2 and IL-10 in epithelial pro...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Selective sparing of goblet cells and paneth cells in the intestine of methotrexate-treated rats
Author(s) :
Verburg, M.
,
Renes, I.B.
,
Meijer, H.P.
,
Taminiau, J.A.
,
Büller, H.A.
,
Einerhand, A.W.C.
,
Dekker, J.
Description :
Proliferation, differentiation, and cell death were studied in small
intestinal and colonic epithelia of rats after treatment with
methotrexate. Days 1-2 after treatment were characterized by decreased
proliferation, increased apoptosis, and decreased numbers and depths of
sm...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Mucin muc2 deficiency and weaning influences the expression of the innate defense genes reg3β, reg3γ and angiogenin-4
Author(s) :
Burger-van Paassen, N.
,
Loonen, L.M.P.
,
Witte-Bouma, J.
,
Korteland-van Male, A.M.
,
Bruijn, A.C., de
,
Sluis, M., van der
Description :
Background Mucin Muc2 is the structural component of the intestinal mucus layer. Absence of Muc2 leads to loss of this layer allowing direct bacterial-epithelial interactions. We hypothesized that absence of the mucus layer leads to increased expression of innate defense peptides. Specifically, we ...
Repository :
Wageningen University and Researchcenter Publications
Language(s) :
English
Specific responses in rat small intestinal epithelial mRNA expression and protein levels during chemotherapeutic damage and regeneration
Author(s) :
Verburg, M.
,
Renes, I.B.
,
Nispen, D.J. van
,
Ferdinandusse, S.
,
Jorritsma, M.
,
Büller, H.A.
,
Einerhand, A.W.C.
,
Dekker, J.
Description :
The rapidly dividing small intestinal epithelium is very sensitive to the
cytostatic drug methotrexate. We investigated the regulation of epithelial
gene expression in rat jejunum during methotrexate-induced damage and
regeneration. Ten differentiation markers were localized on tis...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
Peroxisome proliferator-activated receptor ligand MCC-555 suppresses intestinal polyps in ApcMin/+ mice via extracellular signal-regulated kinase and peroxisome proliferator-activated receptor-dependent pathways
Author(s) :
Yamaguchi, K.
,
Cekanova, M.
,
McEntee, M.F.
,
Yoon, J.H.
,
Fischer, S.
,
Renes, I.B.
,
Seuningen, I. van
,
Baek, S.J.
Description :
A large body of studies has suggested that peroxisome proliferator- activated receptor γ (PPARγ) ligands, such as thiazolidinedione, are potent candidates for chemopreventive agents. MCC-555 is a PPARγ/α dual agonist and has been shown previously to induce apoptosis in vitro; however, the molecular ...
Repository :
RePub (Erasmus University Repository)
Language(s) :
English
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Found 7 documents, displaying page 1 of 1