Author(s) : Payne, Brendan , Bellamy, Richard

Description : Tuberculosis is a major opportunistic infection and cause of death in people with HIV, and often presents as non-pulmonary disease. In people infected with both HIV and Mycobacterium tuberculosis, the annual risk of developing active tuberculosis is 5% to 10%, more than 10 times the rate for p...

Repository : Europe PubMed Central

Language(s) : English

Author(s) : Hudson, Gavin , Wilson, Ian , Payne, Brendan I.A. , Elson, Joanna , Samuels, David C. , Santibanez-Korev, Mauro , Hall, Stephen J.G.

Description : The Chillingham herd of wild Northumbrian cattle remains viable despite over 300 years of in-breeding and a near-homozygous nuclear genome. Here we report the complete mitochondrial DNA sequence using ultra-deep next generation sequencing. Random population sampling of ~ 10% of the extant herd ident...

Repository : Europe PubMed Central

Language(s) : English

Author(s) : Payne, Brendan A.I. , Medhi, Manjul , Ijaz, Samreen , Valappil, Manoj , Savage, Emma J. , Gill, O. Noel , Tedder, Richard

Description :

Repository : Europe PubMed Central

Language(s) : English

Author(s) : Payne, Brendan A.I. , Wilson, Ian J. , Yu-Wai-Man, Patrick , Coxhead, Jonathan , Deehan, David , Horvath, Rita , Taylor, Robert W.

Description : Mammalian cells contain thousands of copies of mitochondrial DNA (mtDNA). At birth, these are thought to be identical in most humans. Here, we use long read length ultra-deep resequencing-by-synthesis to interrogate regions of the mtDNA genome from related and unrelated individuals at unprecedented ...

Repository : Europe PubMed Central

Language(s) : English