Results
author = "Parrish, Susan"
1
Found 5 documents, displaying page 1 of 1
Characterization of a Second Vaccinia Virus mRNA-Decapping Enzyme Conserved in Poxviruses▿
Description :
Vaccinia virus (VACV) encodes enzymes that cap the 5′ end of viral mRNAs, which enhances their stability and translation. Nevertheless, recent studies demonstrated that the VACV D10 protein (VACV-WR_115) decaps mRNA, an enzymatic activity not previously shown to be encoded by a virus. The decapping ...
Repository :
Europe PubMed Central
Language(s) :
English
Characterization of a Vaccinia Virus Mutant with a Deletion of the D10R Gene Encoding a Putative Negative Regulator of Gene Expression
Description :
The D9 and D10 proteins of vaccinia virus are 25% identical to each other, contain a mutT motif characteristic of nudix hydrolases, and are conserved in all sequenced poxviruses. Previous studies indicated that overexpression of D10 and, to a lesser extent, D9 decreased the levels of capped mRNAs an...
Repository :
Europe PubMed Central
Language(s) :
English
Vaccinia virus D10 protein has mRNA decapping activity, providing a mechanism for control of host and viral gene expression
Description :
Previous studies indicated that the vaccinia virus D10 protein, which is conserved in all sequenced poxviruses, participates in the rapid turnover of host and viral mRNAs. D10 contains a motif present in the family of Nudix/MutT enzymes, a subset of which has been shown to enhance mRNA turnover in e...
Repository :
Europe PubMed Central
Language(s) :
English
Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
Description :
Short interfering RNAs (siRNAs) are double-stranded RNAs of
≈21–25 nucleotides that have been shown to function as key
intermediaries in triggering sequence-specific RNA degradation during
posttranscriptional gene silencing in plants and RNA interference in
invertebrates. siRNAs have a character...
Repository :
Europe PubMed Central
Language(s) :
English
The Genomics Education Partnership: Successful Integration of Research into Laboratory Classes at a Diverse Group of Undergraduate Institutions
Author(s) :
Shaffer, Christopher D.
,
Alvarez, Consuelo
,
Bailey, Cheryl
,
Barnard, Daron
,
Bhalla, Satish
,
Chandrasekaran, Chitra
Description :
Genomics is not only essential for students to understand biology but also provides unprecedented opportunities for undergraduate research. The goal of the Genomics Education Partnership (GEP), a collaboration between a growing number of colleges and universities around the country and the Departmen...
Repository :
Europe PubMed Central
Language(s) :
English
1
Found 5 documents, displaying page 1 of 1