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author = "Melchiori, Luca"
1
Found 5 documents, displaying page 1 of 1
Jak2 e eritropoiesi inefficace in beta-talassemia
Author(s) :
Melchiori, Luca
Description :
Ineffective eryhtropoiesis in beta-thalassemia is a process not fully understood. We have undertaken a detailed study on a mouse model of beta-thalassemia, and discovered that, together with apoptosis, erythroid progenitor cells undergo increased proliferation and limited differentiation, exacerbati...
Repository :
Padua@research
Language(s) :
Jak2 e eritropoiesi inefficace in beta-talassemia
Author(s) :
Melchiori, Luca
Description :
Ineffective eryhtropoiesis in beta-thalassemia is a process not fully understood. We have undertaken a detailed study on a mouse model of beta-thalassemia, and discovered that, together with apoptosis, erythroid progenitor cells undergo increased proliferation and limited differentiation, exacerbati...
Repository :
Padua@Research
Language(s) :
Undetermined
β-Thalassemia: HiJAKing Ineffective Erythropoiesis and Iron Overload
Description :
β-thalassemia encompasses a group of monogenic diseases that have in common defective synthesis of β-globin. The defects involved are extremely heterogeneous and give rise to a large phenotypic spectrum, with patients that are almost asymptomatic to cases in which regular blood transfusions ar...
Repository :
Europe PubMed Central
Language(s) :
English
Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia
Author(s) :
Libani, Ilaria V.
,
Guy, Ella C.
,
Melchiori, Luca
,
Schiro, Raffaella
,
Ramos, Pedro
,
Breda, Laura
,
Scholzen, Thomas
Description :
In β-thalassemia, the mechanism driving ineffective erythropoiesis (IE) is insufficiently understood. We analyzed mice affected by β-thalassemia and observed, unexpectedly, a relatively small increase in apoptosis of their erythroid cells compared with healthy mice. Therefore, we sought to determine...
Repository :
Europe PubMed Central
Language(s) :
English
Hepcidin as a therapeutic tool to limit iron overload and improve anemia in β-thalassemic mice
Author(s) :
Gardenghi, Sara
,
Ramos, Pedro
,
Marongiu, Maria Franca
,
Melchiori, Luca
,
Breda, Laura
,
Guy, Ella
,
Muirhead, Kristen
Description :
Excessive iron absorption is one of the main features of β-thalassemia and can lead to severe morbidity and mortality. Serial analyses of β-thalassemic mice indicate that while hemoglobin levels decrease over time, the concentration of iron in the liver, spleen, and kidneys markedly increases. Iron ...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 5 documents, displaying page 1 of 1