Results
author = "Kitaura, Hideki"
1
Found 9 documents, displaying page 1 of 1
RelA/p65 promotes osteoclast differentiation by blocking a RANKL-induced apoptotic JNK pathway in mice
Author(s) :
Vaira, Sergio
,
Alhawagri, Muhammad
,
Anwisye, Imani
,
Kitaura, Hideki
,
Faccio, Roberta
,
Novack, Deborah Veis
Description :
Osteoclasts (OCs) function to reabsorb bone and are responsible for the bone loss associated with inflammatory arthritis and osteoporosis. OC numbers are elevated in most disorders of accelerated bone destruction, reflecting altered rates of precursor differentiation and apoptosis. Both of these pro...
Repository :
Europe PubMed Central
Language(s) :
English
IL-1 mediates TNF-induced osteoclastogenesis
Description :
TNF-induced receptor activator NF-κB ligand (RANKL) synthesis by bone marrow stromal cells is a fundamental component of inflammatory osteolysis. We found that this process was abolished by IL-1 receptor antagonist (IL-1Ra) or in stromal cells derived from type I IL-1 receptor–deficient (IL-1RI–defi...
Repository :
Europe PubMed Central
Language(s) :
English
M-CSF mediates TNF-induced inflammatory osteolysis
Author(s) :
Kitaura, Hideki
,
Zhou, Ping
,
Kim, Hyun-Ju
,
Novack, Deborah V.
,
Ross, F. Patrick
,
Teitelbaum, Steven L.
Description :
TNF-α is the dominant cytokine in inflammatory osteolysis. Using mice whose BM stromal cells and osteoclast precursors are chimeric for the presence of TNF receptors, we found that both cell types mediated the cytokine’s osteoclastogenic properties. The greater contribution was made, however, by str...
Repository :
Europe PubMed Central
Language(s) :
English
NF-κB–inducing kinase controls lymphocyte and osteoclast activities in inflammatory arthritis
Author(s) :
Aya, Kunihiko
,
Alhawagri, Muhammad
,
Hagen-Stapleton, Amanda
,
Kitaura, Hideki
,
Kanagawa, Osami
,
Veis Novack, Deborah
Description :
NF-κB is an important component of both autoimmunity and bone destruction in RA. NF-κB–inducing kinase (NIK) is a key mediator of the alternative arm of the NF-κB pathway, which is characterized by the nuclear translocation of RelB/p52 complexes. Mice lacking functional NIK have no peripheral lymph ...
Repository :
Europe PubMed Central
Language(s) :
English
FHL2 inhibits the activated osteoclast in a TRAF6-dependent manner
Author(s) :
Bai, Shuting
,
Kitaura, Hideki
,
Zhao, Haibo
,
Chen, Ju
,
Müller, Judith M.
,
Schüle, Roland
,
Darnay, Bryant
,
Novack, Deborah V.
Description :
TNF receptor–associated factor 6 (TRAF6) associates with the cytoplasmic domain of receptor activator of NF-κB (RANK). This event is central to normal osteoclastogenesis. We discovered that TRAF6 also interacts with FHL2 (four and a half LIM domain 2), a LIM domain–only protein that functions as a t...
Repository :
Europe PubMed Central
Language(s) :
English
Glucocorticoids suppress bone formation via the osteoclast
Author(s) :
Kim, Hyun-Ju
,
Zhao, Haibo
,
Kitaura, Hideki
,
Bhattacharyya, Sandip
,
Brewer, Judson A.
,
Muglia, Louis J.
,
Ross, F. Patrick
Description :
The pathogenesis of glucocorticoid-induced (GC-induced) bone loss is unclear. For example, osteoblast apoptosis is enhanced by GCs in vivo, but they stimulate bone formation in vitro. This conundrum suggests that an intermediary cell transmits a component of the bone-suppressive effects of GCs to os...
Repository :
Europe PubMed Central
Language(s) :
English
Syk, c-Src, the αvβ3 integrin, and ITAM immunoreceptors, in concert, regulate osteoclastic bone resorption
Author(s) :
Zou, Wei
,
Kitaura, Hideki
,
Reeve, Jennifer
,
Long, Fanxin
,
Tybulewicz, Victor L.J.
,
Shattil, Sanford J.
,
Ginsberg, Mark H.
Description :
In this study, we establish that the tyrosine kinase Syk is essential for osteoclast function in vitro and in vivo. Syk−/− osteoclasts fail to organize their cytoskeleton, and, as such, their bone-resorptive capacity is arrested. This defect results in increased skeletal mass in Syk−/− embryos and d...
Repository :
Europe PubMed Central
Language(s) :
English
The Hemoglobin Receptor Protein of Porphyromonas gingivalis Inhibits Receptor Activator NF-κB Ligand-Induced Osteoclastogenesis from Bone Marrow Macrophages
Author(s) :
Fujimura, Yuji
,
Hotokezaka, Hitoshi
,
Ohara, Naoya
,
Naito, Mariko
,
Sakai, Eiko
,
Yoshimura, Mamiko
,
Narita, Yuka
,
Kitaura, Hideki
Description :
Extracellular proteinaceous factors of Porphyromonas gingivalis, a periodontal pathogen, that influence receptor activator of nuclear factor-κB (NF-κB) ligand (RANKL)-induced osteoclastogenesis from bone marrow macrophages were investigated. The culture supernatant of P. gingivalis had the ability t...
Repository :
Europe PubMed Central
Language(s) :
English
Overexpression of Bcl2 in Osteoblasts Inhibits Osteoblast Differentiation and Induces Osteocyte Apoptosis
Author(s) :
Moriishi, Takeshi
,
Maruyama, Zenjiro
,
Fukuyama, Ryo
,
Ito, Masako
,
Miyazaki, Toshihiro
,
Kitaura, Hideki
,
Ohnishi, Hidetake
Description :
Bcl2 subfamily proteins, including Bcl2 and Bcl-XL, inhibit apoptosis. As osteoblast apoptosis is in part responsible for osteoporosis in sex steroid deficiency, glucocorticoid excess, and aging, bone loss might be inhibited by the upregulation of Bcl2; however, the effects of Bcl2 overexpression on...
Repository :
Europe PubMed Central
Language(s) :
English
1
Found 9 documents, displaying page 1 of 1