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author = "Kinet, Sandrina"
1
Found 8 documents, displaying page 1 of 1
Evidence for a Second Receptor Binding Site on Human Prolactin
Description :
The existence of a second receptor binding site on human prolactin (hPRL) was investigated by site-directed mutagenesis. First, 12 residues of helices 1 and 3 were mutated to alanine. Since none of the resulting mutants exhibit reduced bioactivity in the Nb2 cell proliferation bioassay, the mutated ...
Repository :
ORBi (University of Liège)
Language(s) :
English
Solution structure of human prolactin
Author(s) :
Teilum, K.
,
Hoch, J. C.
,
Goffin, Vincent
,
Kinet, Sandrina
,
Martial, Joseph
,
Kragelund, B. B.
Description :
We report the solution structure of human prolactin determined by NMR spectroscopy. Our result is a significant improvement over a previous structure in terms of number and distribution of distance restraints, regularity of secondary structure, and potential energy. More significantly, the structure...
Repository :
ORBi (University of Liège)
Language(s) :
English
S179D-human PRL, a pseudophosphorylated human PRL analog, is an agonist and not an antagonist
Author(s) :
Bernichtein, Sophie
,
Kinet, Sandrina
,
Jeay, Sébastien
,
Llovera, Marta
,
Madern, Dominique
,
Martial, Joseph
,
Kelly, Paul A.
Description :
For many years, our group has been involved in the development of human PRL antagonists. In two recent publications, S179D-human PRL, a human PRL analog designed to mimic a putative S179-phosphorylated human PRL, was reported to be a highly potent antagonist of human PRL-induced proliferation and si...
Repository :
ORBi (University of Liège)
Language(s) :
English
Glucose transporter 1 expression identifies a population of cycling CD4+CD8+ human thymocytes with high CXCR4-induced chemotaxis
Author(s) :
Swainson, Louise
,
Kinet, Sandrina
,
Manel, Nicolas
,
Battini, Jean-Luc
,
Sitbon, Marc
,
Taylor, Naomi
Description :
GLUT1, the major glucose transporter in peripheral T lymphocytes, is induced upon T cell receptor activation. However, the role of GLUT1 during human thymocyte differentiation remains to be evaluated. Our identification of GLUT1 as the human T lymphotrophic virus (HTLV) receptor has enabled us to us...
Repository :
Europe PubMed Central
Language(s) :
English
Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells
Author(s) :
Kinet Sandrina
,
Swainson Louise
,
Lavanya Madakasira
,
Mongellaz Cedric
,
Montel-Hagen Amélie
,
Craveiro Marco
,
Manel Nicolas
Description :
Abstract
Background
We previously identified the glucose transporter Glut-1, a member of the multimembrane-spanning facilitative nutrient transporter family, as a receptor for both HTLV-1 and HTLV-2. However, a recent report concluded that Glut-1 cannot serve as a receptor for HTLV-...
Repository :
DOAJ-Articles
Language(s) :
English
Isolated receptor binding domains of HTLV-1 and HTLV-2 envelopes bind Glut-1 on activated CD4+ and CD8+ T cells
Author(s) :
Kinet, Sandrina
,
Swainson, Louise
,
Lavanya, Madakasira
,
Mongellaz, Cedric
,
Montel-Hagen, Amélie
,
Craveiro, Marco
Description :
Repository :
Europe PubMed Central
Language(s) :
English
IL-7 differentially regulates cell cycle progression and HIV-1-based vector infection in neonatal and adult CD4+ T cells
Author(s) :
Dardalhon, Valérie
,
Jaleco, Sara
,
Kinet, Sandrina
,
Herpers, Bjorn
,
Steinberg, Marcos
,
Ferrand, Christophe
,
Froger, Delphine
Description :
Differences in the immunological reactivity of umbilical cord (UC) and adult peripheral blood (APB) T cells are poorly understood. Here, we show that IL-7, a cytokine involved in lymphoid homeostasis, has distinct regulatory effects on APB and UC lymphocytes. Neither naive nor memory APB CD4+ cells ...
Repository :
Europe PubMed Central
Language(s) :
English
Glut1-mediated glucose transport regulates HIV infection
Author(s) :
Loisel-Meyer, Séverine
,
Swainson, Louise
,
Craveiro, Marco
,
Oburoglu, Leal
,
Mongellaz, Cédric
,
Costa, Caroline
,
Martinez, Marion
Description :
Cell cycle entry is commonly considered to positively regulate HIV-1 infection of CD4 T cells, raising the question as to how quiescent lymphocytes, representing a large portion of the viral reservoir, are infected in vivo. Factors such as the homeostatic cytokine IL-7 have been shown to render quie...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 8 documents, displaying page 1 of 1