Results
author = "Kaibuchi, Kozo"
Cadherin-mediated Intercellular Adhesion and Signaling Cascades Involving Small GTPases
Description :
Epithelia form physical barriers that separate the internal milieu of the body from its external environment. The biogenesis of functional epithelia requires the precise coordination of many cellular processes. One of the key events in epithelial biogenesis is the establishment of cadherin-dependent...
Repository :
Europe PubMed Central
Language(s) :
English
Rho-Kinase/ROCK: A Key Regulator of the Cytoskeleton and Cell Polarity
Description :
Rho-associated kinase (Rho-kinase/ROCK/ROK) is an effector of the small GTPase Rho and belongs to the AGC family of kinases. Rho-kinase has pleiotropic functions including the regulation of cellular contraction, motility, morphology, polarity, cell division, and gene expression. Pharmacological anal...
Repository :
Europe PubMed Central
Language(s) :
English
Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse
Description :
Plexins are receptors for the axonal guidance molecules known as semaphorins, and the semaphorin 4D (Sema4D) receptor plexin-B1 induces repulsive responses by functioning as an R-Ras GTPase-activating protein (GAP). Here we characterized the downstream signalling of plexin-B1-mediated R-Ras GAP acti...
Repository :
Europe PubMed Central
Language(s) :
English
Unc5B associates with LARG to mediate the action of repulsive guidance molecule
Description :
Neuronal axons are guided by attractive and repulsive cues in their local environment. Because the repulsive guidance molecule A (RGMa) was originally identified as an axon repellent in the visual system, diverse functions in the developing and adult central nervous system have been ascribed to it. ...
Repository :
Europe PubMed Central
Language(s) :
English
The Insert Region of RhoA Is Essential for Rho Kinase Activation and Cellular Transformation
Description :
RhoA is involved in multiple cellular processes, including cytoskeletal organization, gene expression, and transformation. These processes are mediated by a variety of downstream effector proteins. However, which effectors are involved in cellular transformation and how these proteins are activated ...
Repository :
Europe PubMed Central
Language(s) :
English
Binding of APC and dishevelled mediates Wnt5a-regulated focal adhesion dynamics in migrating cells
Author(s) :
Matsumoto, Shinji
,
Fumoto, Katsumi
,
Okamoto, Tetsuji
,
Kaibuchi, Kozo
,
Kikuchi, Akira
Description :
Wnt5a is a representative ligand that activates the Wnt/β-catenin-independent pathway, resulting in the regulation of cell adhesion, migration, and polarity, but its molecular mechanism is poorly understood. This report shows that Dishevelled (Dvl) binds to adenomatous polyposis coli (APC) gene prod...
Repository :
Europe PubMed Central
Language(s) :
English
Flexible Search for Single-Axon Morphology during Neuronal Spontaneous Polarization
Description :
Polarization, a disruption of symmetry in cellular morphology, occurs spontaneously, even in symmetrical extracellular conditions. This process is regulated by intracellular chemical reactions and the active transport of proteins and it is accompanied by cellular morphological changes. To elucidate ...
Repository :
Europe PubMed Central
Language(s) :
English
Interaction between ROCK II and Nucleophosmin/B23 in the Regulation of Centrosome Duplication▿
Author(s) :
Ma, Zhiyong
,
Kanai, Masayuki
,
Kawamura, Kenji
,
Kaibuchi, Kozo
,
Ye, Keqiang
,
Fukasawa, Kenji
Description :
Nucleophosmin (NPM)/B23 has been implicated in the regulation of centrosome duplication. NPM/B23 localizes between two centrioles in the unduplicated centrosome. Upon phosphorylation on Thr199 by cyclin-dependent kinase 2 (CDK2)/cyclin E, the majority of centrosomal NPM/B23 dissociates from centroso...
Repository :
Europe PubMed Central
Language(s) :
English
Activation of Cdc42, Rac, PAK, and Rho-Kinase in Response to Hepatocyte Growth Factor Differentially Regulates Epithelial Cell Colony Spreading and Dissociation
Author(s) :
Royal, Isabelle
,
Lamarche-Vane, Nathalie
,
Lamorte, Louie
,
Kaibuchi, Kozo
,
Park, Morag
Description :
Hepatocyte growth factor (HGF), the ligand for the Met receptor tyrosine kinase, is a potent modulator of epithelial–mesenchymal transition and dispersal of epithelial cells, processes that play crucial roles in tumor development, invasion, and metastasis. Little is known about the Met-dependent pro...
Repository :
Europe PubMed Central
Language(s) :
English
A Mass Conserved Reaction–Diffusion System Captures Properties of Cell Polarity
Author(s) :
Otsuji, Mikiya
,
Ishihara, Shuji
,
Co, Carl
,
Kaibuchi, Kozo
,
Mochizuki, Atsushi
,
Kuroda, Shinya
Description :
Cell polarity is a general cellular process that can be seen in various cell types such as migrating neutrophils and Dictyostelium cells. The Rho small GTP(guanosine 5′-tri phosphate)ases have been shown to regulate cell polarity; however, its mechanism of emergence has yet to be clarified. We first...
Repository :
Europe PubMed Central
Language(s) :
English