Results
author = "Jonjic, Stipan"
Monoclonal antibodies reactive with swine lymphocytes
Description :
A panel of monoclonal antibodies (mAb) with specificity for swine leukocytes was prepared by somatic cell hybridization with the use of spleen cells from mice immunized with swine thymocytes. The reactivity of two mAb (295/33 and 122/28), which both immunoprecipitated from the surface of swine leuko...
Repository :
Open Access LMU
Language(s) :
Undetermined
Manipulation of NKG2D Ligands by Cytomegaloviruses: Impact on Innate and Adaptive Immune Response
Description :
NKG2D is a potent activating receptor expressed on NK cells, NKT cells, γδ T cells, and CD8 T cells. NKG2D recognizes cell surface molecules structurally related to MHC class I proteins induced by infection or other type of cellular stress. The engagement of NKG2D leads to NK cell cytotoxicity and c...
Repository :
Europe PubMed Central
Language(s) :
English
Bone Turnover in Homozygous β2-Microglobulin Knock-Out Mice Does not Differ from That of Their Heterozygous Littermates
Description :
Repository :
Humboldt University of Berlin, GERMANY, Document Server
Language(s) :
Undetermined
Systematic Excision of Vector Sequences from the BAC-Cloned Herpesvirus Genome during Virus Reconstitution
Description :
Recently the mouse cytomegalovirus (MCMV) genome was cloned as an infectious bacterial artificial chromosome (BAC) (M. Messerle, I. Crnković, W. Hammerschmidt, H. Ziegler, and U. H. Koszinowski, Proc. Natl. Acad. Sci. USA 94:14759–14763, 1997). The virus obtained from this construct is attenuated in...
Repository :
Europe PubMed Central
Language(s) :
English
Antibodies Are Not Essential for the Resolution of Primary Cytomegalovirus Infection but Limit Dissemination of Recurrent Virus
Author(s) :
Jonjic, Stipan
,
Pavic, Ivica
,
Polic, Bojan
,
Crnkovic, Irena
,
Lucin, Pero
,
Koszinowski, Ulrich H.
Description :
Virus shedding from the epithelial cells of the serous acini of salivary glands is a major source
for the horizontal transmission of cytomegalovirus. These cells are, different to other tissues,
exempt from CD8 T lymphocyte control. CD4 T lymphocytes are essential to terminate the
productive infecti...
Repository :
Open Access LMU
Language(s) :
Undetermined
Site-restricted persistent cytomegalovirus infection after selective long-term depletion of CD4+ T lymphocytes
Author(s) :
Jonjic, Stipan
,
Mutter, Wolfgang
,
Weiland, Frank
,
Reddehase, Matthias J.
,
Koszinowski, Ulrich H.
Description :
We have established a murine model system for exploring the ability of a CD4 subset-deficient host to cope with cytomegalovirus infection, and reported three findings. First, an antiviral response of the CD8 subset of T lymphocytes could be not only initiated but also maintained for a long period of...
Repository :
Open Access LMU
Language(s) :
Undetermined
Cytolytic T lymphocyte recognition of the murine cytomegalovirus nonstructural immediate-early protein pp89 expressed by recombinant vaccinia virus
Author(s) :
Volkmer, Hansjürgen
,
Bertholet, Christine
,
Jonjic, Stipan
,
Wittek, Riccardo
,
Koszinowski, Ulrich H.
Description :
The murine immediate-early (IE) protein pp89 is a nonstructural virus- encoded phosphoprotein residing in the nucleus of infected cells, where it acts as transcriptional activator. Frequency analysis has shown that in BALB/c mice the majority of virus-specific CTL recognize IE antigens. The present ...
Repository :
Open Access LMU
Language(s) :
Undetermined
Restoration of cytomegalovirus antigen presentation by gamma interferon combats viral escape.
Author(s) :
Hengel, Hartmut
,
Lucin, Pero
,
Jonjic, Stipan
,
Ruppert, Siegfried
,
Koszinowski, Ulrich H.
Description :
An immediate-early protein of murine cytomegalovirus (MCMV), pp89, elicits an immunodominant and protective major histocompatibility complex (MHC) class I Ld-restricted CD8+ T-lymphocyte response. Remarkably, presentation of the naturally processed peptide of pp89, the nonapeptide YPHFMPTNL, is abol...
Repository :
Open Access LMU
Language(s) :
Undetermined
Gamma interferon-dependent clearance of cytomegalovirus infection in salivary glands
Description :
Cytomegalovirus (CMV), similar to other members of the Herpesviridae family, can establish both persistent and latent infections. Each of the CMVs that are found in many animal species replicates in the salivary gland, and oral secretion represents a source of horizontal transmission. Locally restri...
Repository :
Open Access LMU
Language(s) :
Undetermined
Efficacious control of cytomegalovirus infection after long-term depletion of CD8+ T lymphocytes
Description :
Although the relative contribution of different immune effector functions to clearing tissues of cytomegalovirus is controversial, the contribution of CD8+ T lymphocytes has generally been accepted as essential. In this report, we show that under certain conditions the CD8+ T-lymphocyte subset can b...
Repository :
Open Access LMU
Language(s) :
Undetermined