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author = "Jansen, Jacob G."
1
Found 6 documents, displaying page 1 of 1
The BRCT domain of mammalian Rev1 is involved in regulating DNA translesion synthesis
Author(s) :
Jansen, Jacob G.
,
Tsaalbi-Shtylik, Anastasia
,
Langerak, Petra
,
Calléja, Fabienne
,
Meijers, Caro M.
,
Jacobs, Heinz
Description :
Rev1 is a deoxycytidyl transferase associated with DNA translesion synthesis (TLS). In addition to its catalytic domain, Rev1 possesses a so-called BRCA1 C-terminal (BRCT) domain. Here, we describe cells and mice containing a targeted deletion of this domain. Rev1B/B mice are healthy, fertile and di...
Repository :
Europe PubMed Central
Language(s) :
English
Strand-biased defect in C/G transversions in hypermutating immunoglobulin genes in Rev1-deficient mice
Author(s) :
Jansen, Jacob G.
,
Langerak, Petra
,
Tsaalbi-Shtylik, Anastasia
,
van den Berk, Paul
,
Jacobs, Heinz
,
de Wind, Niels
Description :
Somatic hypermutation of Ig genes enables B cells of the germinal center to generate high-affinity immunoglobulin variants. Key intermediates in somatic hypermutation are deoxyuridine lesions, introduced by activation-induced cytidine deaminase. These lesions can be processed further to abasic sites...
Repository :
Europe PubMed Central
Language(s) :
English
Transcription-coupled repair and apoptosis provide specific protection against transcription-associated mutagenesis by ultraviolet light
Description :
Recent data reveal that gene transcription affects genome stability in mammalian cells. For example, transcription of DNA that is damaged by the most prevalent exogenous genotoxin, UV light, induces nucleotide substitutions and chromosomal instability, collectively called UV-induced transcription-as...
Repository :
Europe PubMed Central
Language(s) :
English
Separate Domains of Rev1 Mediate Two Modes of DNA Damage Bypass in Mammalian Cells▿ †
Author(s) :
Jansen, Jacob G.
,
Tsaalbi-Shtylik, Anastasia
,
Hendriks, Giel
,
Gali, Himabindu
,
Hendel, Ayal
,
Johansson, Fredrik
Description :
The Y family DNA polymerase Rev1 has been proposed to play a regulatory role in the replication of damaged templates. To elucidate the mechanism by which Rev1 promotes DNA damage bypass, we have analyzed the progression of replication on UV light-damaged DNA in mouse embryonic fibroblasts that conta...
Repository :
Europe PubMed Central
Language(s) :
English
Error-prone translesion replication of damaged DNA suppresses skin carcinogenesis by controlling inflammatory hyperplasia
Author(s) :
Tsaalbi-Shtylik, Anastasia
,
Verspuy, Johan W. A.
,
Jansen, Jacob G.
,
Rebel, Heggert
,
Carlée, Leone M.
,
van der Valk, Martin A.
Description :
The induction of skin cancer involves both mutagenic and proliferative responses of the epidermis to ultraviolet (UV) light. It is believed that tumor initiation requires the mutagenic replication of damaged DNA by translesion synthesis (TLS) pathways. The mechanistic basis for the induction of prol...
Repository :
Europe PubMed Central
Language(s) :
English
Alkylpurine–DNA–N-Glycosylase Knockout Mice Show Increased Susceptibility to Induction of Mutations by Methyl Methanesulfonate
Author(s) :
Elder, Rhoderick H.
,
Jansen, Jacob G.
,
Weeks, Robert J.
,
Willington, Mark A.
,
Deans, Bryan
,
Watson, Amanda J.
,
Mynett, Kurt J.
Description :
Alkylpurine-DNA-N-glycosylase (APNG) null mice have been generated by homologous recombination in embryonic stem cells. The null status of the animals was confirmed at the mRNA level by reverse transcription-PCR and by the inability of cell extracts of tissues from the knockout (ko) animals to relea...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 6 documents, displaying page 1 of 1