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author = "Gurer, Cagan"
1
Found 7 documents, displaying page 1 of 1
Specific Incorporation of Heat Shock Protein 70 Family Members into Primate Lentiviral Virions
Description :
To determine if any heat shock proteins are incorporated into human immunodeficiency virus type 1 (HIV-1) virions in a manner similar to that of the peptidyl-prolyl isomerase cyclophilin A, we probed purified virions with antibodies against heat shock proteins Hsp27, Hsp40, Hsp60, Hsp70, Hsc70, and ...
Repository :
Europe PubMed Central
Language(s) :
English
Covalent Modification of Human Immunodeficiency Virus Type 1 p6 by SUMO-1
Description :
The p6 domain of the human immunodeficiency virus type 1 (HIV-1) Gag polyprotein mediates virion budding from infected cells via protein-protein contacts with the class E vacuolar protein sorting factors, Tsg101 and AIP1/ALIX. Interaction with Tsg101 is strengthened by covalent attachment of monoval...
Repository :
Europe PubMed Central
Language(s) :
English
Virus-specific CD4+ T cells: ready for direct attack
Description :
CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent studies demonstrate that they can also kill infected cells directly. A new paper shows that highly efficient processing of Epstein Barr virus (EBV) glycoproteins for presentation on MHC class II makes virus-tra...
Repository :
Europe PubMed Central
Language(s) :
English
ATPγS Disrupts Human Immunodeficiency Virus Type 1 Virion Core Integrity
Description :
Heat shock protein 70 (Hsp70) is incorporated within the membrane of primate lentiviral virions. Here we demonstrate that Hsp70 is also incorporated into oncoretroviral virions and that it remains associated with membrane-stripped human immunodeficiency virus type 1 (HIV-1) virion cores. To determin...
Repository :
Europe PubMed Central
Language(s) :
English
As2O3 Enhances Retroviral Reverse Transcription and Counteracts Ref1 Antiviral Activity
Author(s) :
Berthoux, Lionel
,
Towers, Greg J.
,
Gurer, Cagan
,
Salomoni, Paolo
,
Pandolfi, Pier Paolo
,
Luban, Jeremy
Description :
Potent drugs such as cyclosporine have provided effective probes of signal transduction pathways and, as well, of human immunodeficiency virus type 1 (HIV-1) replication mechanisms. Recently, it was reported that As2O3, a drug used to treat acute promyelocytic leukemia (PML), stimulates HIV-1 replic...
Repository :
Europe PubMed Central
Language(s) :
English
Targeting the nuclear antigen 1 of Epstein-Barr virus to the human endocytic receptor DEC-205 stimulates protective T-cell responses
Author(s) :
Gurer, Cagan
,
Strowig, Till
,
Brilot, Fabienne
,
Pack, Maggi
,
Trumpfheller, Christine
,
Arrey, Frida
,
Park, Chae Gyu
Description :
Dendritic cells (DCs) express many endocytic receptors that deliver antigens for major histocompatibility class (MHC) I and II presentation to CD8+ and CD4+ T cells, respectively. Here, we show that targeting Epstein-Barr virus (EBV) nuclear antigen 1 (EBNA1) to one of them, the human multilectin DE...
Repository :
Europe PubMed Central
Language(s) :
English
Priming of protective T cell responses against virus-induced tumors in mice with human immune system components
Author(s) :
Strowig, Till
,
Gurer, Cagan
,
Ploss, Alexander
,
Liu, Yi-Fang
,
Arrey, Frida
,
Sashihara, Junji
,
Koo, Gloria
,
Rice, Charles M.
Description :
Many pathogens that cause human disease infect only humans. To identify the mechanisms of immune protection against these pathogens and also to evaluate promising vaccine candidates, a small animal model would be desirable. We demonstrate that primary T cell responses in mice with reconstituted huma...
Repository :
Europe PubMed Central
Language(s) :
English
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Found 7 documents, displaying page 1 of 1