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author = "Gissmann, L"

Found 22 documents, displaying page 1 of 3

Human papilloma virus DNA: physical mapping and genetic heterogeneity.

Author(s) : Gissmann, L , Hausen, H Z
Description : The molecular weight of three preparations of human papilloma virus DNA derived from different plantar warts was determined by agarose gel electrophoresis or electron microscopic contour length measurement. It was found to amount to approximately 4.9 X 10(6). Analysis of this DNA after sequential di...
Repository : Europe PubMed Central
Language(s) : English

Targeted expression of the E6 and E7 oncogenes of human papillomavirus type 16 in the epidermis of transgenic mice elicits generalized epidermal hyperplasia involving autocrine factors.

Description : The E6 and E7 early genes of human papillomavirus type 16 have been shown in vitro to play a central role in the transforming capability of this virus. To explore their effects on differentiating epithelial cells in vivo, we used a bovine cytokeratin 10 (K10) promoter to target the expression of E6 ...
Repository : Europe PubMed Central
Language(s) : English

Papillomavirus sequences integrate near cellular oncogenes in some cervical carcinomas.

Description : The chromosomal locations of cellular sequences flanking integrated papillomavirus DNA in four cervical carcinoma cell lines and a primary cervical carcinoma have been determined. The two human papillomavirus (HPV) 16 flanking sequences derived from the tumor were localized to chromosome regions 20p...
Repository : Europe PubMed Central
Language(s) : English

Kinetic selection of HPV 16 E6/E7-directed antisense nucleic acids: anti-proliferative effects on HPV 16-transformed cells.

Description : The E6/E7-coding sequences of the human papillomavirus type 16 (HPV 16) were probed for kinetic accessibility in vitro by pools of catalytic antisense RNA. Only long-chain complementary RNA and very few antisense sequences with a 3' portion complementary to a 10 nt window within unspliced and splice...
Repository : Europe PubMed Central
Language(s) : English

Molecular cloning and characterization of human papilloma virus DNA derived from a laryngeal papilloma.

Description : Papilloma virus DNA from a laryngeal papilloma was cloned in phage lambda L 47 and characterized after cleavage with different restriction enzymes. Hybridization with the DNAs of human papilloma virus types 1, 2, 3, 4, 5, and 8 showed no homology under stringent hybridization conditions. Human papil...
Repository : Europe PubMed Central
Language(s) : English

Molecular cloning of viral DNA from human genital warts.

Description : The DNA of human papilloma virus type 6 (HPV 6) has been cloned in Escherichia coli K-12 by using pBR322 as vector. The DNA was cloned at the BamHI and EcoRI cleavage sites. This DNA was mapped by employing further restriction endonucleases and by terminal labeling. No major differences were noted a...
Repository : Europe PubMed Central
Language(s) : English

Characterization of human papillomavirus type 13 from focal epithelial hyperplasia Heck lesions.

Description : Focal epithelial hyperplasia Heck lesions of a Turkish patient were shown to contain papillomavirus-specific DNA, which was molecularly cloned into bacteriophage lambda. It proved to be related to human papillomavirus (HPV) type 6 DNA and HPV type 11 DNA. Reassociation kinetics revealed a cross-hybr...
Repository : Europe PubMed Central
Language(s) : English

Human papillomavirus type 48.

Description : The cloning and partial characterization of the genome of human papillomavirus (HPV) type 48 is presented. Hybridization and short DNA sequence analyses permitted the alignment of the genome to the HPV genetic map.
Repository : Europe PubMed Central
Language(s) : English

Found 22 documents, displaying page 1 of 3