Results
author = "Galán, Juan Carlos "
CTX-M Enzymes: Origin and Diffusion
Description :
CTX-M β-lactamases are considered a paradigm in the evolution of a resistance mechanism. Incorporation of different chromosomal blaCTX-M related genes from different species of Kluyvera has derived in different CTX-M clusters. In silico analyses have shown that this event has occurred at least nine ...
Repository :
Europe PubMed Central
Language(s) :
English
Macrolide Resistance in Peptostreptococcus spp. Mediated by ermTR: Possible Source of Macrolide-Lincosamide-Streptogramin B Resistance in Streptococcus pyogenes
Description :
Eighty percent (21 of 26) of macrolide-resistant Peptostreptococcus strains studied harbored the ermTR gene. This methyltransferase gene is also the most frequently found gene among macrolide-lincosamide-streptogramin B-resistant Streptococcus pyogenes strains. Transfer of the ermTR gene from Peptos...
Repository :
Europe PubMed Central
Language(s) :
English
Antibiotics as selectors and accelerators of diversity in the mechanisms of resistance: from the resistome to genetic plasticity in the β-lactamases world
Description :
Antibiotics and antibiotic resistance determinants, natural molecules closely related to bacterial physiology and consistent with an ancient origin, are not only present in antibiotic-producing bacteria. Throughput sequencing technologies have revealed an unexpected reservoir of antibiotic resistanc...
Repository :
Europe PubMed Central
Language(s) :
English
Haemophilus influenzae blaROB-1 Mutations in Hypermutagenic ΔampC Escherichia coli Conferring Resistance to Cefotaxime and β-Lactamase Inhibitors and Increased Susceptibility to Cefaclor
Author(s) :
Galán, Juan-Carlos
,
Morosini, María-Isabel
,
Baquero, María-Rosario
,
Reig, Milagro
,
Baquero, Fernando
Description :
The clinical use of cefaclor has been shown to enrich Haemophilus influenzae populations harboring cefaclor-hydrolyzing ROB-1 β-lactamase. Such a selective process may lead to the increased use of extended-spectrum cephalosporins or β-lactams plus β-lactamase inhibitors and, eventually, resistance t...
Repository :
Europe PubMed Central
Language(s) :
English
Integron Content of Extended-Spectrum-β-Lactamase-Producing Escherichia coli Strains over 12 Years in a Single Hospital in Madrid, Spain
Author(s) :
Machado, Elisabete
,
Cantón, Rafael
,
Baquero, Fernando
,
Galán, Juan-Carlos
,
Rollán, Azucena
,
Peixe, Luísa
,
Coque, Teresa M.
Description :
The contribution of integrons to the dissemination of extended-spectrum β-lactamases (ESBL) was analyzed on all ESBL-producing Escherichia coli isolates from 1988 to 2000 at Ramón y Cajal Hospital. We studied 133 E. coli pulsed-field gel electrophoresis types: (i) 52 ESBL-producing clinical strains ...
Repository :
Europe PubMed Central
Language(s) :
English
Fosfomycin and Rifampin Disk Diffusion Tests for Detection of Escherichia coli Mutator Strains
Author(s) :
Galán, Juan-Carlos
,
Tato, Marta
,
Baquero, María-Rosario
,
Turrientes, Carmen
,
Baquero, Fernando
,
Martinez, José-Luis
Description :
A simple method, using commercial disks to detect Escherichia coli mutator strains, is proposed. The breakpoint for detecting strains with a mutation frequency ≥5 × 10−7 was established at ≥70 and ≥20 colonies in the inhibition zone of fosfomycin and rifampin disks, respectively, after seeding 100 μ...
Repository :
Europe PubMed Central
Language(s) :
English
Mutational Events in Cefotaximase Extended-Spectrum β-Lactamases of the CTX-M-1 Cluster Involved in Ceftazidime Resistance ▿
Author(s) :
Novais, Ângela
,
Cantón, Rafael
,
Coque, Teresa M.
,
Moya, Andrés
,
Baquero, Fernando
,
Galán, Juan Carlos
Description :
CTX-M β-lactamases, which show a high cefotaxime hydrolytic activity, constitute the most prevalent extended-spectrum β-lactamase (ESBL) type found among clinical isolates. The recent explosive diversification of CTX-M enzymes seems to have taken place due to the appearance of more efficient enzymes...
Repository :
Europe PubMed Central
Language(s) :
English
Complete Genome Sequence of Acidaminococcus intestini RYC-MR95, a Gram-Negative Bacterium from the Phylum Firmicutes
Author(s) :
D'Auria, Giuseppe
,
Galán, Juan-Carlos
,
Rodríguez-Alcayna, Manuel
,
Moya, Andrés
,
Baquero, Fernando
,
Latorre, Amparo
Description :
Acidaminococcus intestini belongs to the family Acidaminococcaceae, order Selenomonadales, class Negativicutes, phylum Firmicutes. Negativicutes show the double-membrane system of Gram-negative bacteria, although their chromosomal backbone is closely related to that of Gram-positive bacteria of the ...
Repository :
Europe PubMed Central
Language(s) :
English
In117, an Unusual In0-Like Class 1 Integron Containing CR1 and blaCTX-M-2 and Associated with a Tn21-Like Element
Author(s) :
Valverde, Aránzazu
,
Cantón, Rafael
,
Galán, Juan Carlos
,
Nordmann, Patrice
,
Baquero, Fernando
,
Coque, Teresa M.
Description :
An unusual In0-like class 1 integron containing a common region that includes the putative recombinase gene named orf513 (CR1) and blaCTX-M-2 was characterized from Escherichia coli. The integron contained an unusual gene cassette array, estX-aadA1, embedded between the 5′-conserved segment (5′-CS) ...
Repository :
Europe PubMed Central
Language(s) :
English
Mutation rate is reduced by increased dosage ofmutL gene in Escherichia coli K-12
Author(s) :
Galán, Juan Carlos
,
Turrientes, María del Carmen
,
Baquero, María del Rosario
,
Rodríguez Alcayna, Manuel
,
Martínez Amado, Jorge
Description :
This work was supported by the grants
BIO2005-04278, LSHM-CT-2005-018705 and LSHM-CT-2005-518152.
,
Peer reviewed
Repository :
Digital.CSIC
Language(s) :
English