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author = "Botchkareva, Natalia V."
1
Found 6 documents, displaying page 1 of 1
The Role of the Hairless (hr) Gene in the Regulation of Hair Follicle Catagen Transformation
Author(s) :
Panteleyev, Andrei A.
,
Botchkareva, Natalia V.
,
Sundberg, John P.
,
Christiano, Angela M.
,
Paus, Ralf
Description :
Mice that carry a mutation at the hairless (hr) locus develop seemingly normal hair follicles (HF) but shed their hairs completely soon after birth. Histologically, their HFs degenerate into characteristic utriculi and dermal cysts shortly after the entry of the HF into the first regression phase (c...
Repository :
Europe PubMed Central
Language(s) :
English
MicroRNA-21 is an important downstream component of BMP signalling in epidermal keratinocytes
Author(s) :
Ahmed, Mohammed I.
,
Mardaryev, Andrei N.
,
Lewis, Christopher J.
,
Sharov, Andrey A.
,
Botchkareva, Natalia V.
Description :
Bone morphogenetic proteins (BMPs) play essential roles in the control of skin development, postnatal tissue remodelling and tumorigenesis. To explore whether some of the effects of BMP signalling are mediated by microRNAs, we performed genome-wide microRNA (miRNA) screening in primary mouse keratin...
Repository :
Europe PubMed Central
Language(s) :
English
New Roles for Glial Cell Line-Derived Neurotrophic Factor and Neurturin : Involvement in Hair Cycle Control
Author(s) :
Botchkareva, Natalia V.
,
Botchkarev, Vladimir A.
,
Welker, Pia
,
Airaksinen, Matti
,
Roth, Wera
,
Suvanto, Petro
,
Müller-Röver, Sven
Description :
Glial cell line-derived neurotrophic factor (GDNF), neurturin (NTN), and their receptors, GDNF family receptor α-1 (GFRα-1) and GDNF family receptor α-2 (GFRα-2), are critically important for kidney and nervous system development. However, their role in skin biology, specifically in hair growth cont...
Repository :
Europe PubMed Central
Language(s) :
English
Abundant Production of Brain-Derived Neurotrophic Factor by Adult Visceral Epithelia : Implications for Paracrine and Target-Derived Neurotrophic Functions
Author(s) :
Lommatzsch, Marek
,
Braun, Armin
,
Mannsfeldt, Anne
,
Botchkarev, Vladimir A.
,
Botchkareva, Natalia V.
,
Paus, Ralf
Description :
Brain-derived neurotrophic factor (BDNF) plays a crucial role for the survival of visceral sensory neurons during development. However, the physiological sources and the function of BDNF in the adult viscera are poorly described. We have investigated the cellular sources and the potential role of BD...
Repository :
Europe PubMed Central
Language(s) :
English
A New Role for Neurotrophin-3 : Involvement in the Regulation of Hair Follicle Regression (Catagen)
Author(s) :
Botchkarev, Vladimir A.
,
Welker, Pia
,
Albers, Kathryn M.
,
Botchkareva, Natalia V.
,
Metz, Martin
,
Lewin, Gary R.
Description :
Nervous system and hair follicle epithelium share a common ectodermal origin, and some neurotrophins (NTs) can modulate keratinocyte proliferation and apoptosis. Therefore, it is reasonable to ask whether NTs are also involved in hair growth control. Here, we show that the expression of NT-3 and its...
Repository :
Europe PubMed Central
Language(s) :
English
p53 Involvement in the Control of Murine Hair Follicle Regression
Author(s) :
Botchkarev, Vladimir A.
,
Komarova, Elena A.
,
Siebenhaar, Frank
,
Botchkareva, Natalia V.
,
Sharov, Andrei A.
,
Komarov, Pavel G.
Description :
p53 is a transcription factor mediating a variety of biological responses including apoptotic cell death. p53 was recently shown to control apoptosis in the hair follicle induced by ionizing radiation and chemotherapy, but its role in the apoptosis-driven physiological hair follicle regression (cata...
Repository :
Europe PubMed Central
Language(s) :
English
1
Found 6 documents, displaying page 1 of 1