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author = "Bellahcene, Akeila"
1
Found 8 documents, displaying page 1 of 1
La protéine P53, protectrice de l'intégrité du génome: rôle dans la genèse des cancers Protein P53, Protector of Genome Integrity: Its Role in Carcinogenesis
Author(s) :
Bellahcene, Akeila
,
Merville, Marie-Paule
,
Gielen Jacques
,
Lambotte, René
,
Simar, Léon
,
Castronovo, Vincenzo
Description :
L'homéostasie des tissus de l'organisme est le résultat d'un équilibre dynamique stable entre des facteurs de régulation positifs et négatifs. Ceux-ci contrôlent la prolifération des cellules et déterminent leur appartenance tissulaire. Des données récentes indiquent que l'apparition des cancers ré...
Repository :
ORBi (University of Liège)
Language(s) :
French
Differential proteomic analysis of a human breast tumor and its matched bone metastasis identifies cell membrane and extracellular proteins associated with bone metastasis
Author(s) :
Dumont, Bruno
,
Castronovo, Vincenzo
,
Peulen, Olivier
,
BLETARD, Noëlla
,
Clézardin, Philippe
,
Delvenne, Philippe
Description :
The classical fate of metastasizing breast cancer cells is to seed and form secondary colonies in bones. The molecules closely associated with these processes are predominantly present at the cell surface and in the extracellular space, establishing the first contacts with the target tissue. In this...
Repository :
ORBi (University of Liège)
Language(s) :
English
Cell Membrane Proteomic Analysis Identifies Proteins Differentially Expressed in Osteotropic Human Breast Cancer Cells12
Author(s) :
Kischel, Philippe
,
Guillonneau, François
,
Dumont, Bruno
,
Bellahcène, Akeila
,
Stresing, Verena
,
Clézardin, Philippe
Description :
Metastatic breast cancer cells are characterized by their high propensity to colonize the skeleton and form bone metastases, causing major morbidity and mortality. Identifying key proteins involved in the osteotropic phenotype would represent a major step toward the development of both new prognosti...
Repository :
Europe PubMed Central
Language(s) :
English
Dual function of ERRalpha in breast cancer and bone metastasis formation: implication of VEGF and osteoprotegerin.
Author(s) :
Fradet, Anais
,
Sorel, Helene
,
Bouazza, Lamia
,
Goehrig, Delphine
,
Depalle, Baptiste
,
Bellahcene, Akeila
,
Castronovo, Vincenzo
Description :
Bone metastasis is a complication occurring in up to 70% of advanced breast cancer patients. The estrogen receptor-related receptor alpha (ERRalpha) has been implicated in breast cancer and bone development, prompting us to examine whether ERRalpha may function in promoting the osteolytic growth of ...
Repository :
ORBi (University of Liège)
Language(s) :
English
The angiogenesis suppressor gene AKAP12 is under the epigenetic control of HDAC7 in endothelial cells.
Author(s) :
Turtoi, Andrei
,
Mottet, Denis
,
Matheus, Nicolas
,
Dumont, Bruno
,
Peixoto, Paul
,
Hennequière, Vincent
,
Deroanne, Christophe
Description :
Histone deacetylases (HDACs) are a family of 18 enzymes that deacetylate lysine residues of both histone and nonhistone proteins and to a large extent govern the process of angiogenesis. Previous studies have shown that specific inhibition of HDAC7 blocks angiogenesis both in vitro and in vivo. Howe...
Repository :
ORBi (University of Liège)
Language(s) :
English
Expression of Histone Deacetylase 8, a Class I Histone Deacetylase, Is Restricted to Cells Showing Smooth Muscle Differentiation in Normal Human Tissues
Author(s) :
Waltregny, David
,
de Leval, Laurence
,
Glénisson, Wendy
,
Ly Tran, Siv
,
North, Brian J.
,
Bellahcène, Akeila
,
Weidle, Ulrich
Description :
Histone deacetylases (HDACs) were originally identified as nuclear enzymes involved in gene transcription regulation. Until recently, it was thought that their activity was restricted within the nucleus, with histones as unique substrates. The demonstration that specific HDACs deacetylate nonhistone...
Repository :
Europe PubMed Central
Language(s) :
English
Both osteopontin-c and osteopontin-b splicing isoforms exert pro-tumorigenic roles in prostate cancer cells.
Author(s) :
Tilli, T. M.
,
Mello, K. D.
,
Ferreira, L. B.
,
Matos, A. R.
,
Accioly, M. T.
,
Faria, P. A.
,
Bellahcene, Akeila
,
Castronovo, Vincenzo
Description :
BACKGROUND: Alternative splicing of the osteopontin (opn, spp1) gene generates three protein splicing isoforms (OPN-SI), designated as OPNa, OPNb, and OPNc, which have demonstrated specific roles in different tumor models. This work aims to investigate the roles of each OPN-SI in prostate cancer (PC...
Repository :
ORBi (University of Liège)
Language(s) :
English
Galectin-1 in melanoma biology and related neo-angiogenesis processes.
Author(s) :
Mathieu, Véronique
,
de Lassalle, Elisabeth Martin
,
Toelen, Jaan
,
Mohr, Thomas
,
Bellahcène, Akeila
,
Van Goietsenoven, Gwendoline
Description :
Aggressiveness of advanced melanomas relates in part to their marked propensity to develop neoangiogenesis and metastases. Among its numerous pro-cancer roles, galectin (gal)-1 expressed and/or secreted by both cancer and endothelial cells stimulates proliferation and angiogenesis. This study first ...
Repository :
DIAL - Dépôt Institutionnel de l'Académie Louvain
Language(s) :
English
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Found 8 documents, displaying page 1 of 1