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Aegerter-Wilmsen, T; Smith, A C; Christen, A J; Aegerter, C M; Hafen, E; Basler, K (2010). Exploring the effects of mechanical feedback on epithelial topology. Development, 137(3):499-506. (1)
Affolter, M; Nellen, D; Nussbaumer, U; Basler, K (1994). Multiple requirements for the receptor serine/threonine kinase thick veins reveal novel functions of TGF beta homologs during Drosophila embryogenesis. Development, 120(11):3105-3117. (1)
Basler, K; Christen, B; Hafen, E (1991). Ligand-independent activation of the sevenless receptor tyrosine kinase changes the fate of cells in the developing Drosophila eye. Cell, 64(6):1069-1081. (1)
Basler, K; Edlund, T; Jessell, T M; Yamada, T (1993). Control of cell pattern in the neural tube: regulation of cell differentiation by dorsalin-1, a novel TGF beta family member. Cell, 73(4):687-702. (1)
Basler, K; Oesch, B; Scott, M; Westaway, D; Wälchli, M; Groth, D F; McKinley, M P; Prusiner, S B; Weissmann, C (1986). Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell, 46(3):417-428. (1)
Bellotto, M; Bopp, D; Senti, K A; Burke, R; Deak, P; Maroy, P; Dickson, B J; Basler, K; Hafen, E (2002). Maternal-effect loci involved in Drosophila oogenesis and embryogenesis: P element-induced mutations on the third chromosome. International Journal of Developmental Biology, 41(1):149-157. (1)
Burke, R; Basler, K (1996). Dpp receptors are autonomously required for cell proliferation in the entire developing Drosophila wing. Development, 122(7):2261-2269. (1)
Burke, R; Nellen, D; Bellotto, M; Hafen, E; Senti, K A; Dickson, B J; Basler, K (1999). Dispatched, a novel sterol-sensing domain protein dedicated to the release of cholesterol-modified hedgehog from signaling cells. Cell, 99(7):803-815. (1)
Dahmann, C; Basler, K (2000). Opposing transcriptional outputs of Hedgehog signaling and engrailed control compartmental cell sorting at the Drosophila A/P boundary. Cell, 100(4):411-422. (1)
Dambly-Chaudière, C; Jamet, E; Burri, M; Bopp, D; Basler, K; Hafen, E; Dumont, N; Spielmann, P; Ghysen, A; Noll, M (1992). The paired box gene pox neuro: a determinant of poly-innervated sense organs in Drosophila. Cell, 69(1):159-172. (1)
Gerlitz, O; Basler, K (2002). Wingful, an extracellular feedback inhibitor of wingless. Genes and Development, 16(9):1055-1059. (1)
Gerlitz, O; Nellen, D; Ottiger, M; Basler, K (2002). A screen for genes expressed in Drosophila imaginal discs. International Journal of Developmental Biology, 46(1):173-176. (1)
Geuking, P; Narasimamurthy, R; Lemaitre, B; Basler, K; Leulier, F (2009). A non-redundant role for Drosophila Mkk4 and hemipterous/Mkk7 in TAK1-mediated activation of JNK. PLoS ONE, 4(11):e7709. (1)
Goetze, S; Qeli, E; Mosimann, C; Staes, A; Gerrits, B; Roschitzki, B; Mohanty, S; Niederer, E M; Laczko, E; Timmerman, E; Lange, V; Hafen, E; Aebersold, R; Vandekerckhove, J; Basler, K; Ahrens, C H; Gevaert, K; Brunner, E (2009). Identification and functional characterization of N-terminally acetylated proteins in Drosophila melanogaster. PLoS Biology, 7(11):e1000236. (1)
Grieder, N C; Nellen, D; Burke, R; Basler, K; Affolter, M (1995). Schnurri is required for Drosophila Dpp signaling and encodes a zinc finger protein similar to the mammalian transcription factor PRDII-BF1. Cell, 81(5):791-800. (1)
Hasson, P; Müller, B; Basler, K; Paroush, Z (2001). Brinker requires two corepressors for maximal and versatile repression in Dpp signalling. The EMBO Journal, 20(20):5725-5736. (1)
Hausmann, G; von Mering, C; Basler, K (2009). The hedgehog signaling pathway: where did it come from? PLoS Biology, 7(6):e1000146. (1)
Herr, P; Basler, K (2012). Porcupine-mediated lipidation is required for Wnt recognition by Wls. Developmental Biology, 361(2):392-402. (1)
Hoffmans, R; Basler, K (2004). Identification and in vivo role of the Armadillo-Legless interaction. Development, 131(17):4393-4400. (1)
Hoffmans, R; Städeli, R; Basler, K (2005). Pygopus and legless provide essential transcriptional coactivator functions to armadillo/beta-catenin. Current Biology, 15(13):1207-1211. (1)
Hödl, M; Basler, K (2009). Transcription in the absence of histone H3.3. Current Biology, 19(14):1221-1226. (1)
ISSN: 1544-9173 (1)
Katanaev, V L; Solis, G P; Hausmann, G; Buestorf, S; Katanayeva, N; Schrock, Y; Stuermer, C A O; Basler, K (2008). Reggie-1/flotillin-2 promotes secretion of the long-range signalling forms of Wingless and Hedgehog in Drosophila. The EMBO Journal, 27(3):509-521. (1)
Kramps, T; Peter, O; Brunner, E; Nellen, D; Froesch, B; Chatterjee, S; Murone, M; Züllig, S; Basler, K (2002). Wnt/wingless signaling requires BCL9/legless-mediated recruitment of pygopus to the nuclear beta-catenin-TCF complex. Cell, 109(1):47-60. (1)
M0014 (1)
Ma, Y; Erkner, A; Gong, R; Yao, S; Taipale, J; Basler, K; Beachy, P A (2002). Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell, 111(1):63-75. (1)
Moreno, E; Basler, K (2004). dMyc transforms cells into super-competitors. Cell, 117(1):117-129. (1)
Moreno, E; Yan, M; Basler, K (2002). Evolution of TNF signaling mechanisms: JNK-dependent apoptosis triggered by Eiger, the Drosophila homolog of the TNF superfamily. Current Biology, 12(14):1263-1268. (1)
Méthot, N; Basler, K (1999). Hedgehog controls limb development by regulating the activities of distinct transcriptional activator and repressor forms of Cubitus interruptus. Cell, 96(6):819-831. (1)
Méthot, N; Basler, K (2000). Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus. Development, 127(18):4001-4010. (1)
Méthot, N; Basler, K (2001). An absolute requirement for Cubitus interruptus in Hedgehog signaling. Development, 128(5):733-742. (1)
Müller, B; Basler, K (2000). The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites. Development, 127(14):2999-3007. (1)
Müller, B; Hartmann, B; Pyrowolakis, G; Affolter, M; Basler, K (2003). Conversion of an extracellular Dpp/BMP morphogen gradient into an inverse transcriptional gradient. Cell, 113(2):221-233. (1)
Nairz, K; Zipperlen, P; Dearolf, C; Basler, K; Hafen, E (2004). A reverse genetic screen in Drosophila using a deletion-inducing mutagen. Genome Biology, 5(10):R83. (1)
Nellen, D; Affolter, M; Basler, K (1994). Receptor serine/threonine kinases implicated in the control of Drosophila body pattern by decapentaplegic. Cell, 78(2):225-237. (1)
Nellen, D; Burke, R; Struhl, G; Basler, K (1996). Direct and long-range action of a DPP morphogen gradient. Cell, 85(3):357-368. (1)
PLOS BIOLOGY (1)
Pyrowolakis, G; Hartmann, B; Müller, B; Basler, K; Affolter, M (2004). A simple molecular complex mediates widespread BMP-induced repression during Drosophila development. Developmental Cell, 7(2):229-240. (1)
Ruberte, E; Marty, T; Nellen, D; Affolter, M; Basler, K (1995). An absolute requirement for both the type II and type I receptors, punt and thick veins, for dpp signaling in vivo. Cell, 80(6):889-897. (1)
Schilling, S; Willecke, M; Aegerter-Wilmsen, T; Cirpka, O A; Basler, K; von Mering, C (2011). Cell-sorting at the a/p boundary in the Drosophila wing primordium: a computational model to consolidate observed non-local effects of hh signaling. PLoS Computational Biology, 7(4):e1002025. (1)
Schwank, G; Dalessi, S; Yang, S-F; Yagi, R; de Lachapelle, A M; Affolter, M; Bergmann, S; Basler, K (2011). Formation of the long range dpp morphogen gradient. PLoS Biology, 9(7):e1001111. (1)
Schwank, G; Restrepo, S; Basler, K (2008). Growth regulation by Dpp: an essential role for Brinker and a non-essential role for graded signaling levels. Development, 135(24):4003-4013. (1)
Schweizer, L; Nellen, D; Basler, K (2003). Requirement for Pangolin/dTCF in Drosophila Wingless signaling. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 100(10):5846-5851. (1)
Sivasankaran, R; Vigano, M A; Müller, B; Affolter, M; Basler, K (2000). Direct transcriptional control of the Dpp target omb by the DNA binding protein Brinker. The EMBO Journal, 19(22):6162-6172. (1)
Struhl, G; Basler, K (1993). Organizing activity of wingless protein in Drosophila. Cell, 72(4):527-540. (1)
Végh, M; Basler, K (2003). A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary. Genetics, 163(4):1427-1438. (1)
Zecca, M; Basler, K; Struhl, G (1995). Sequential organizing activities of engrailed, hedgehog and decapentaplegic in the Drosophila wing. Development, 121(8):2265-2278. (1)
Zecca, M; Basler, K; Struhl, G (1996). Direct and long-range action of a wingless morphogen gradient. Cell, 87(5):833-844. (1)
Zipperlen, P; Nairz, K; Rimann, I; Basler, K; Hafen, E; Hengartner, M; Hajnal, A (2005). A universal method for automated gene mapping. Genome Biology, 6(2):R19. (1)
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author = "Basler, K"
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Found 49 documents, displaying page 1 of 5

Identification and in vivo role of the Armadillo-Legless interaction.

Author(s) : Hoffmans, R , Basler, K
Description : The Wnt signalling system controls many fundamental processes during animal development and its deregulation has been causally linked to colorectal cancer. Transduction of Wnt signals entails the association of beta-catenin with nuclear TCF DNA-binding factors and the subsequent activation of target...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Transcription in the absence of histone H3.3

Author(s) : Hödl, M , Basler, K
Description : Di- and trimethylation of histone H3 lysine 4 (H3K4me2 and H3K4me3) are hallmarks of chromatin at active genes. The major fraction of K4-methylated histone H3 is the variant H3 (termed H3.3 in Drosophila), which replaces canonical H3 (H3.2) in transcribed genes. Here, we genetically address the in v...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Porcupine-mediated lipidation is required for Wnt recognition by Wls

Author(s) : Herr, P , Basler, K
Description : Wnt proteins are members of a conserved family of secreted signaling ligands and play crucial roles during development and in tissue homeostasis. There is increasing evidence that aberrant Wnt production is an underlying cause of dysregulated Wnt signaling, however little is known about this process...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

dMyc transforms cells into super-competitors.

Author(s) : Moreno, E , Basler, K
Description : Overexpression of myc protooncogenes has been implicated in the genesis of many human tumors. Myc proteins seem to regulate diverse biological processes, but their role in tumorigenesis remains enigmatic. Here we use Drosophila imaginal discs to mimic situations in which cells with unequal levels of...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

A genetic screen for hedgehog targets involved in the maintenance of the Drosophila anteroposterior compartment boundary

Author(s) : Végh, M , Basler, K
Description : The development of multicellular organisms requires the establishment of cell populations with different adhesion properties. In Drosophila, a cell-segregation mechanism underlies the maintenance of the anterior (A) and posterior (P) compartments of the wing imaginal disc. Although engrailed (en) ac...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Wingful, an extracellular feedback inhibitor of wingless

Author(s) : Gerlitz, O , Basler, K
Description : Secreted peptide signals control many fundamental processes during animal development. Proper responses to these signals require cognate inducible feedback antagonists. Here we report the identification of a novel Drosophila Wingless (Wg) target gene, wingful (wf), and show that it encodes a potent ...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

An absolute requirement for Cubitus interruptus in Hedgehog signaling.

Author(s) : Méthot, N , Basler, K
Description : Hedgehog (Hh) proteins play diverse organizing roles in animal development by regulating gene expression in responding cells. Several components of the Hh signal transduction pathway have been identified, yet their precise role in mediating the various outputs of the pathway is still poorly understo...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Suppressor of fused opposes hedgehog signal transduction by impeding nuclear accumulation of the activator form of Cubitus interruptus.

Author(s) : Méthot, N , Basler, K
Description : Hedgehog controls the expression of key developmental genes through the conversion of the transcription factor Cubitus interruptus (Ci) into either an activator (Ci[act]) or a repressor (Ci[rep]) form. Proteolytic cleavage of full-length Ci is important for the generation of Ci[rep], but little is k...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

The repressor and activator forms of Cubitus interruptus control Hedgehog target genes through common generic gli-binding sites.

Author(s) : Müller, B , Basler, K
Description : The Drosophila Gli homolog Cubitus interruptus (Ci) controls the transcription of Hedgehog (Hh) target genes. A repressor form of Ci arises in the absence of Hh signalling by proteolytic cleavage of intact Ci, whereas an activator form of Ci is generated in response to the Hh signal. These different...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English

Organizing activity of wingless protein in Drosophila.

Author(s) : Struhl, G , Basler, K
Description : The adult appendages of Drosophila are formed from imaginal discs, sheets of epithelial cells that proliferate during larval development and differentiate during metamorphosis. wingless (wg, DWnt-1) protein, a putative signaling molecule, is expressed only in prospective ventral cells in each of the...
Repository : Zurich Open Repository and Archive (ZORA)
Language(s) : English
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Found 49 documents, displaying page 1 of 5