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Developmental regulation of beta-carboline-induced inhibition of glycine-evoked responses depends on glycine receptor beta subunit expression

Description : In this work, we show that beta-carbolines, which are known negative allosteric modulators of GABA A receptors, inhibit glycine-induced currents of embryonic mouse spinal cord and hippocampal neurons. In both cell types, beta-carboline-induced inhibition of glycine receptor (GlyR)-mediated responses...
Language(s) : English
Subject(s) : RAT SPINAL-CORD; BENZODIAZEPINE RECEPTORS; SYNAPTIC-TRANSMISSION; IN-VITRO; NEURONS; CURRENTS; MODULATION; LIGAND; ADULT; BRAIN
Publisher(s) : Bethesda : AMER SOC PHARMACOLOGY EXPERIMENTAL THERAPEUTICS
Contributor(s) :
Source(s) :
Publication Date(s) : 2006-11-19