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Ir-CPI, a coagulation contact phase inhibitor from the tick Ixodes ricinus, inhibits thrombus formation without impairing hemostasis

Description : Blood coagulation starts immediately after damage to the vascular endothelium. This system is essential for minimizing blood loss from an injured blood vessel but also contributes to vascular thrombosis. Although it has long been thought that the intrinsic coagulation pathway is not important for cl...
Language(s) : English
Subject(s) : Venous Thrombosis , Thrombosis , Thrombin , Sequence Analysis, Protein , Recombinant Proteins , Rats , Protein Binding , Partial Thromboplastin Time , Mice , Male , Kallikreins , Ixodes , Humans , Fibrinolysis , Fibrinolysin , Factor XIa , Factor XIIa , Disease Models, Animal , Blood Coagulation Factor Inhibitors , Blood Coagulation , Animals
Publisher(s) : New York Rockefeller Univ Press
Contributor(s) : UCL - MD/MINT - Département de médecine interne , UCL - MD/FARM - Ecole de pharmacie , UCL - MD/ESP - Ecole de santé publique
Source(s) :
Publication Date(s) : 2009-01-01