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• (author = "Reynaud, Claude-Agnès")
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Contribution of DNA polymerase eta to immunoglobulin gene hypermutation in the mouse.

Author(s) : Delbos, Frédéric , De Smet, Annie , Faili, Ahmad , Aoufouchi, Said , Weill, Jean-Claude , Reynaud, Claude-Agnès
Description : The mutation pattern of immunoglobulin genes was studied in mice deficient for DNA polymerase eta, a translesional polymerase whose inactivation is responsible for the xeroderma pigmentosum variant (XP-V) syndrome in humans. Mutations show an 85% G/C biased pattern, similar to that reported for XP-V...
Repository : HAL - Hyper Article on Line , View repository documents
Language(s) : English
Subject(s) : [SDV:IMM] Life Sciences/Immunology , immunoglobulin genes , somatic hypermutation , polymerase eta
Publisher(s) :
Contributor(s) :
Source(s) : Journal of Experimental Medicine / The Journal of Experimental Medicine
Publication Date(s) : 2005-04-18