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• (author = "Reynaud, Claude-Agnès")

Document details

DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.

Author(s) : Delbos, Frédéric , Aoufouchi, Said , Faili, Ahmad , Weill, Jean-Claude , Reynaud, Claude-Agnès

Description : Mutations at A/T bases within immunoglobulin genes have been shown to be generated by a repair pathway involving the DNA-binding moiety of the mismatch repair complex constituted by the MSH2-MSH6 proteins, together with DNA polymerase eta (pol eta). However, residual A/T mutagenesis is still observe...

Repository : HAL - Hyper Article on Line , View repository documents

Language(s) : English

Subject(s) : [SDV:IMM] Life Sciences/Immunology , immunoglobulin genes , somatic hypermutation , polymerase eta

Publisher(s) :

Contributor(s) :

Source(s) : Journal of Experimental Medicine / The Journal of Experimental Medicine

Publication Date(s) : 2007-01-22

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