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Transfer of central nervous system autoantigens and presentation in secondary lymphoid organs

Description : Dendritic cells are thought to regulate tolerance induction vs immunization by transferring Ags and peripheral signals to draining lymph nodes (LN). However, whether myelin Ag transfer and presentation in LN occurs during demyelinating brain disease is unknown. In this study, we ...
Language(s) : English
Subject(s) : Neck , Animals , Humans , Research Support, Non-U.S. Gov't , *Antigen Presentation , Antigen-Presenting Cells/immunology/metabolism/pathology , Autoantigens/analysis/*metabolism , Axilla , Biological Markers/analysis , Brain/*immunology/*metabolism/pathology , Callithrix , Cell Aggregation/immunology , Encephalomyelitis, Autoimmune, Experimental/immunology/metabolism/pathology , Epitopes, T-Lymphocyte/analysis , Inguinal Canal , Lymph Nodes/chemistry/*immunology/*metabolism/pathology , Macaca fascicularis , Multiple Sclerosis/immunology/metabolism/pathology , Macaca mulatta , Myelin Basic Proteins/analysis/immunology/metabolism , Protein Transport/immunology , Spleen , T-Lymphocytes/chemistry/immunology/pathology
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Publication Date(s) : 2002-01-01