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• (author = "Pochet, Lionel")
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Novel 3-carboxamide-coumarins as potent and selective FXIIa inhibitors.

Author(s) : Robert, Séverine , Bertolla, Carine , Masereel, Bernard , Dogné, Jean-Michel , Pochet, Lionel
Description : Recently, FXIIa was highlighted as an original attractive target for the development of new anticoagulant drugs with low rates of therapy-related hemorrhages. In this work, we describe the development of a new series of 3-carboxamide-coumarins that are the first potent and selective nonpeptidic inhi...
Repository : DIAL - Dépôt Institutionnel de l'Académie Louvain , View repository documents
Language(s) : English
Subject(s) : Amides , Anticoagulants , Coumarins , Factor XIIa , Structure-Activity Relationship
Publisher(s) :
Contributor(s) : FUNDP
Source(s) :
Publication Date(s) : 2008-01-01