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Bcl-2 and Bax exert opposing effects on Ca2+ signaling, which do not depend on their putative pore-forming region

Description : Recent work has shown that Bcl-2 and other antiapoptotic proteins partially deplete the endoplasmic reticulum (ER) Ca2+ store and that this alteration of Ca2+ signaling reduces cellular sensitivity to apoptotic stimuli. We expressed in HeLa cells Bcl-2, Bax, and Bcl-2/Bax chimeras in which the putat...
Language(s) : Undetermined
Subject(s) : CYTOCHROME-C RELEASE, ENDOPLASMIC-RETICULUM, INTRACELLULAR CA2+, CELL-DEATH, APOPTOSIS, CALCIUM, MITOCHONDRIA, PROTEIN, HOMEOSTASIS, RECEPTOR
Publisher(s) : AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
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Source(s) :
Publication Date(s) : 2004-12-24