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Missense mutations associated with familial Alzheimer's disease in Sweden lead to the production of the amyloid peptide without internalization of its precursor.

Description : Production of soluble amyloid peptide precursor (APP) and amyloid peptide (A beta) was measured in CHO cells transfected by the wild-type APP 695 cDNA sequence or by the same sequence carrying missense mutations associated with familial Alzheimer's disease in Sweden. Deletion of the C-terminal domai...
Language(s) : English
Subject(s) : Alzheimer Disease , Amino Acid Sequence , Amyloid beta-Protein , Amyloid beta-Protein Precursor , Animals , Base Sequence , CHO Cells , Cricetinae , DNA Primers , Gene Expression , Humans , Molecular Sequence Data , Mutation , Polymerase Chain Reaction , Protein Processing, Post-Translational , Recombinant Proteins , Restriction Mapping , Sequence Deletion , Sweden , Transfection
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Contributor(s) : UCL
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Publication Date(s) : 1996-01-01