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• (author = "Lahl, Katharina")

Document details

Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease.

Author(s) : Lahl, Katharina , Loddenkemper, Christoph , Drouin, Cathy , Freyer, Jennifer , Arnason, Jon , Eberl, Gérard , Hamann, Alf

Description : The scurfy mutant mouse strain suffers from a fatal lymphoproliferative disease leading to early death within 3-4 wk of age. A frame-shift mutation of the forkhead box transcription factor Foxp3 has been identified as the molecular cause of this multiorgan autoimmune disease. Foxp3 is a central cont...

Repository : HAL - Hyper Article on Line , View repository documents

Language(s) : English

Subject(s) : [SDV:IMM] Life Sciences/Immunology

Publisher(s) :

Contributor(s) :

Source(s) : Journal of Experimental Medicine / The Journal of Experimental Medicine

Publication Date(s) : 2007-01-22

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