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Common Genetic Variants and Modification of Penetrance of BRCA2-Associated Breast Cancer

Author(s) : Gaudet, MM , Kirchhoff, T , Green, T , Vijai, J , Korn, JM , Guiducci, C , Segre, AV , McGee, K , McGuffog, L , Kartsonaki, C , Morrison, J
Description : The considerable uncertainty regarding cancer risks associated with inherited mutations of BRCA2 is due to unknown factors. To investigate whether common genetic variants modify penetrance for BRCA2 mutation carriers, we undertook a two-staged genome-wide association study in BRCA2 mutation carriers...
Repository : UCL Eprints , View repository documents
Language(s) : Undetermined
Subject(s) : BRCA2 MUTATION CARRIERS, SUSCEPTIBILITY GENES, RECURRENT BRCA1, RISK, POPULATION, MODEL, PREDISPOSITION, ASSOCIATION, PHENOTYPE, FREQUENCY
Publisher(s) : PUBLIC LIBRARY SCIENCE
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Source(s) :
Publication Date(s) : 2010-10-01