Author(s) : Berk-Planken, I.I.L. , Hoogerbrugge, N. , Stolk, R.P. , Bootsma, A.H. , Jansen, H.

Description : OBJECTIVE: Hepatic lipase (HL) is involved in the metabolism of several lipoproteins and may contribute to the atherogenic lipid profile in type 2 diabetes. Little is known about the effect of cholesterol synthesis inhibitors on HL activity in relation to sex and the hepatic lipase...

Repository : RePub (Erasmus University Repository) , View repository documents

Language(s) : English

Subject(s) : Male , Dose-Response Relationship, Drug , Aged , Female , Humans , Middle aged , Research Support, Non-U.S. Gov't , Liver/*enzymology , Polymorphism, Genetic , Promoter Regions (Genetics) , Double-Blind Method , Variation (Genetics) , Alleles , African Continental Ancestry Group , Diabetes Mellitus, Type 2/*drug therapy/*enzymology/ethnology/genetics , Enzyme Inhibitors/*administration & dosage , European Continental Ancestry Group , Heptanoic Acids/*administration & dosage , Heterozygote , Hyperlipidemia/etiology , Lipase/*antagonists & inhibitors/genetics/metabolism , Pyrroles/*administration & dosage , Sex Characteristics

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Publication Date(s) : 2003-01-01