flag flag  

Pre-emptive immunotherapy with CD8-depleted donor lymphocytes after CD34-selected allogeneic peripheral blood stem cell transplantation.

Description : BACKGROUND AND OBJECTIVES: To maximize graft-versus-leukemia (GVL) effects while minimizing the risk of graft-versus-host disease (GVHD), we undertook a study of allogeneic CD34-selected peripheral blood stem cell (PBSC) transplantation followed by CD8-depleted donor lymphocyte infusion (DLI). DESIG...
Language(s) : English
Subject(s) : Adolescent , Adult , Antigens, CD8 , Cytomegalovirus Infections/etiology , Feasibility Studies , Female , Graft Survival , Graft vs Host Disease/epidemiology/prevention & control , Graft vs Leukemia Effect , Hematologic Neoplasms/mortality/therapy , Hematopoietic Stem Cell Transplantation/adverse effects/statistics & numerical data , Histocompatibility , Humans , Incidence , Leukapheresis , Lymphocyte Depletion , Lymphocyte Transfusion/statistics & numerical data , Male , Middle Aged , Survival Analysis , Transplantation, Homologous/statistics & numerical data , Treatment Outcome , Virus Activation , Human health sciences :: Hematology [D11] , Sciences de la santé humaine :: Hématologie [D11]
Publisher(s) :
Contributor(s) :
Source(s) : &ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&jtitle=Haematologica&issn=0390-6078&eissn=1592-8721&volume=87&issue=1&pages=78-88&pub=Ferrata+Storti+Foundation&place=Pavia&place=Italy
Publication Date(s) : 2002-01-01