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The diversity, structure and regulation of beta-lactamases.

Description : beta-Lactamase production is responsible for the appearance of a large number of pathogenic bacterial strains exhibiting a high degree of resistance to beta-lactam antibiotics. A large number of enzymes have been described with very diverse primary structures and catalytic profiles. Nevertheless, al...
Language(s) : English
Subject(s) : Gene Expression Regulation, Bacterial , Gram-Negative Bacteria/enzymology/genetics , Gram-Positive Bacteria/enzymology/genetics , Models, Molecular , Serine/chemistry , Structure-Activity Relationship , Zinc/chemistry , beta-Lactamases/biosynthesis/chemistry/classification/metabolism , Life sciences :: Biochemistry, biophysics & molecular biology [F05] , Sciences du vivant :: Biochimie, biophysique & biologie moléculaire [F05]
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Source(s) : &ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&jtitle=Cellular+and+Molecular+Life+Sciences+%3A+CMLS&issn=1420-682X&eissn=1420-9071&volume=54&issue=4&pages=341-6&pub=Birkh%C3%A4user&place=Basel&place=Switzerland
Publication Date(s) : 1998-01-01