Author(s) : Alvarez,, J , Coulombe, A , Cazorla, O , Ugur, M , Rauzier, J. M , Magyar, J , Mathieu, E. L , Boulay, G , Souto, R , Bideaux, P

Description : Extracellular purines and pyrimidines have major effects on cardiac rhythm and contraction. ATP/UTP are released during various physiopathological conditions, such as ischemia, and despite degradation by ectonucleotidases, their interstitial concentrations can markedly increase, a fact that is clear...

Repository : Debreceni Egyetem elektronikus Archivumanak (DEA) , View repository documents

Language(s) : Undetermined

Subject(s) : Adenosine Triphosphate/ metabolism , Animals , Arrhythmias, Cardiac/etiology/metabolism , Cell Membrane Permeability , Disease Models, Animal , Dogs , Estrenes/pharmacology , Humans , Male , Membrane Potentials , Mice , Mice, Knockout , Myocardial Infarction/complications/metabolism , Myocytes, Cardiac/drug effects/enzymology/ metabolism , Patch-Clamp Techniques , Phosphodiesterase Inhibitors/pharmacology , Phospholipase C beta/antagonists and inhibitors/metabolism , Pyrrolidinones/pharmacology , Rats , Rats, Wistar , Receptors, Purinergic P2/genetics/ metabolism , Signal Transduction/drug effects , TRPC Cation Channels/ metabolism , Uridine Triphosphate/ metabolism

Publisher(s) :

Contributor(s) : INSERM U-637, Physiopathologie cardiovasculaire, CHU Arnaud de Villeneuve, F-34295 Montpellier, France , Élettani Intézet -- 10 , ÁOK -- OEC , Debreceni Egyetem

Source(s) :

Publication Date(s) : 2010-03-25