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The multigenic structure of the MHC locus contributes to positive selection efficiency: A role for MHC class II gene-genespecific

Description : The study of T cell positive selection in the thymus has long been focused on the specificity of the MHC-TCR interactions, making use of genetically manipulated mice that display TCR specificities or selecting peptides of limited diversity. However, little is known on the role of the MHC molecules i...
Language(s) : English
Subject(s) : MHC , Multigenic , Repertoire development , Thymic selection
Publisher(s) : Wiley
Contributor(s) :
Source(s) :
Publication Date(s) : 2010-05-14